Document Detail


A numerical measure of amino acid residues similarity based on the analysis of their surroundings in natural protein sequences.
MedLine Citation:
PMID:  11522918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A measure of similarity between amino acid residues based on the analysis of the surroundings of each residue in primary structures of native proteins is proposed. The statistical data used for this purpose were obtained from the analysis of 168,808 protein sequences, which comprise the Protein Identification Research database (release 63). Using various threshold values of the proposed measure, amino acid residues were classified into several groups. The classification elaborated differs essentially from groupings previously used. The numerical measure of amino acid residues similarity can be used in site-directed mutagenesis studies for the prediction of probability of local spatial rearrangements in proteins.
Authors:
S I Rogov; A N Nekrasov
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Protein engineering     Volume:  14     ISSN:  0269-2139     ISO Abbreviation:  Protein Eng.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-08-27     Completed Date:  2001-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8801484     Medline TA:  Protein Eng     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-63     Citation Subset:  IM    
Affiliation:
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St. 16/10, GSP-7, Moscow 117997, Russia.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Amino Acids / chemistry*
Animals
Databases, Factual
Databases, Protein
Humans
Hydrophobicity
Mathematics
Mutagenesis, Site-Directed
Numerical Analysis, Computer-Assisted
Peptides / chemistry*
Protein Conformation
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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