| The number of tumour-infiltrating TIA-1+ cytotoxic T cells but not FOXP3+ regulatory T cells predicts outcome in diffuse large B-cell lymphoma. | |
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MedLine Citation:
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PMID: 17456059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prognostic significance of tumour-infiltrating lymphocytes (TILs) in patients with diffuse large B-cell lymphoma (DLBCL) remains controversial. Furthermore, the possible impact of regulatory T cells (T(regs)) on survival in DLBCL is still unknown. We performed a retrospective study on the immunohistochemical expression of cytotoxic cells and T(regs), and their correlation with survival in 195 DLBCL patients. Patients with a small number of cytotoxic T-cell intracytoplasmic antigen-1 (TIA-1)+ T cells (< or =260 cells/mm(2) tumour area; n = 52) had significantly better outcome than patients with a large number (>260 cells/mm(2); n = 143); progression-free survival (PFS) at 5 years was 67% vs. 50% (P = 0.03) and overall survival (OS) was 73% vs. 57% (P = 0.03). In multivariate analysis, the low TIA-1+ group still had a better PFS (relative risk 0.75, 95% confidence interval 0.31-0.99; P = 0.05). The number of forkhead box protein 3 (FOXP3)+ T(regs) had no influence on PFS (P = 0.89) or OS (P = 0.75). These results suggest that immunohistochemical analysis of cytotoxic T cells at time of diagnosis could provide additional prognostic information. The lack of correlation between the number of FOXP3+ cells and survival could possibly indicate that tumour-infiltrating T(regs) are of less clinical importance in DLBCL. However, these findings need to be explored in functional studies. |
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Authors:
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Sverker Hasselblom; Margret Sigurdadottir; Ulrika Hansson; Herman Nilsson-Ehle; Börje Ridell; Per-Ola Andersson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of haematology Volume: 137 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-25 Completed Date: 2007-06-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 364-73 Citation Subset: IM |
Affiliation:
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Section of Haematology and Coagulation, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg, Sweden. sverker.hasselblom@vgregion.se |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Disease-Free Survival Female Forkhead Transcription Factors* Humans Immunohistochemistry Lymphocyte Count Lymphocytes, Tumor-Infiltrating / immunology* Lymphoma, B-Cell / immunology Lymphoma, Large B-Cell, Diffuse / immunology* Male Middle Aged Poly(A)-Binding Proteins* Prognosis Proportional Hazards Models Retrospective Studies Risk Survival Rate T-Lymphocyte Subsets / immunology* T-Lymphocytes, Cytotoxic / immunology* T-Lymphocytes, Regulatory / immunology |
| Chemical | |
Reg. No./Substance:
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0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/Poly(A)-Binding Proteins; 145138-44-9/TIA1 protein, human |
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