Document Detail


The number of triplet repeats in five brain-expressed loci with CAG repeats is not associated with schizophrenia.
MedLine Citation:
PMID:  9187009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously shown that large expansions of CAG (CTG) triplets are associated both with schizophrenia itself and with an early age-at-onset of the disease. However, the repeat expansion detection (RED) method used did not provide a chromosomal location for the expanded region(s) (Morris et al., 1995). In a further study of our schizophrenic and control patients, we have now examined the length of the repeated sequence in five loci that are expressed in brain and are known to contain CAG repeat regions (Li et al., 1993). No enlarged repeat regions were identified; it is unlikely therefore that expansions at any of these five loci can account for expansions of up to 136 triplets identified by the RED method.
Authors:
E J Gaitonde; S Sivagnanasundaram; A G Morris; P J McKenna; J D Mollon; D M Hunt
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Schizophrenia research     Volume:  25     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-07-28     Completed Date:  1997-07-28     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  111-6     Citation Subset:  IM    
Affiliation:
Department of Experimental Psychology, University of Cambridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Age of Onset
Alleles
Base Sequence
Brain / pathology*
Chromosome Aberrations
Chromosome Disorders
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 3
DNA Primers
Female
Humans
Male
Molecular Sequence Data
Polymorphism, Genetic
Schizophrenia / genetics*,  pathology*
Trinucleotide Repeats*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/DNA Primers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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