Document Detail

The number of spermatozoa collected with testicular sperm extraction is a novel predictor of intracytoplasmic sperm injection outcome in non-obstructive azoospermic patients.
MedLine Citation:
PMID:  21240295     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine the relationships between monitors of spermatogenesis and predictors of the intracytoplasmic sperm injection (ICSI) outcome in patients with non-obstructive azoospermia (NOA) undergoing testicular sperm extraction (TESE). Seventy-nine patients with NOA (mean age: 43.6±5.2 years), each of whom yielded (97 000±3040) spermatozoa with conventional TESE, were considered in our analysis. Their partners (mean age: 35.8±5.1 years) underwent a total of 184 ICSI cycles; 632 oocytes were collected, 221 oocytes were injected, 141 oocytes were fertilized, 121 embryos were obtained, 110 embryos were transferred, 14 clinical pregnancies were achieved and only one miscarriage occurred. Multivariate regression analysis indicated relationships between the percentage of fertilized oocytes, transferred embryos and clinical pregnancies with the following variable values: female partner's age, number of spermatozoa collected, testicular volume, male partner's levels of follicle stimulating hormone (FSH), number of oocytes collected, number of oocytes injected and number of ICSI cycles. A significant inverse relationship was found between female partner's age or male partner's FSH levels and biochemical pregnancies. A significant direct relationship emerged between the number of ICSI cycles and the percentage of oocytes fertilized, embryos transferred and biochemical pregnancies, and between the number of spermatozoa collected per testicular biopsy and biochemical pregnancies. The number of spermatozoa was positively linked to the number of clinical pregnancies, independent of the number of ICSI cycles and the number of oocytes collected/injected. The number of spermatozoa collected, FSH level and testicular volume are monitors of spermatogenesis linked to ICSI success.
Giorgio Cavallini; Maria Cristina Magli; Andor Crippa; Silvia Resta; Giovanni Vitali; Anna Pia Ferraretti; Luca Gianaroli
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Publication Detail:
Type:  Journal Article     Date:  2011-01-17
Journal Detail:
Title:  Asian journal of andrology     Volume:  13     ISSN:  1745-7262     ISO Abbreviation:  Asian J. Androl.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-08     Completed Date:  2011-07-15     Revised Date:  2013-09-17    
Medline Journal Info:
Nlm Unique ID:  100942132     Medline TA:  Asian J Androl     Country:  China    
Other Details:
Languages:  eng     Pagination:  312-6     Citation Subset:  IM    
Andros-Italia, Outpatient Clinic of Ferrara, 44121 Ferrara, Italy.
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MeSH Terms
Azoospermia / pathology*,  therapy*
Middle Aged
Multivariate Analysis
Pregnancy Outcome
Retrospective Studies
Sperm Count*
Sperm Injections, Intracytoplasmic*
Sperm Retrieval*

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