| The number of cells used for immunotherapy of repeated spontaneous abortion influences pregnancy outcome. | |
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MedLine Citation:
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PMID: 1453389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One hundred and sixty-eight women were immunized on a single occasion with paternal mononuclear cells (MNC) for recurrent spontaneous abortion (RSA) and pregnancy outcomes were analysed with respect to the number of MNC given. The study was done in a prospective sequential fashion using all MNC recoverable from a unit of the spouse's blood and both patients and investigators were blinded as to the number of cells injected. Women receiving low and mid-range doses of MNC (58-305 x 10(6) and 308-567 x 10(6), respectively) had a significantly higher pregnancy success rate (57%) than those receiving the high (568-2677 x 10(6)) dose of MNC (41%). In 77 consecutive patients the diameter of the largest immediate skin flare reaction at the site of subcutaneous injection was recorded. No correlation was found between the skin flare response and the number of MNC injected. Our data suggest that a blinded trial of paternal MNC immunization comparing what appears to be optimum numbers of cells (100-550 million) to a low dose inoculum (e.g., 10 million), again noting the sizes of the skin flare reactions, might answer questions about efficacy and placebo effects of immunotherapy for RSA. |
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Authors:
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J B Smith; F S Cowchock; J A Lata; B T Hankinson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of reproductive immunology Volume: 22 ISSN: 0165-0378 ISO Abbreviation: J. Reprod. Immunol. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-12-31 Completed Date: 1992-12-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 217-24 Citation Subset: IM |
Affiliation:
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Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual
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immunology,
therapy* Female Humans Immunotherapy* Leukocyte Count Leukocytes, Mononuclear / immunology, transplantation* Male Pregnancy Pregnancy Outcome |
| Grant Support | |
ID/Acronym/Agency:
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R01-HD-25629/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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