Document Detail

The nucleus accumbens is not critically involved in mediating the effects of a safety signal on behavior.
MedLine Citation:
PMID:  15257308     Owner:  NLM     Status:  MEDLINE    
Although considerable progress has been made towards understanding the neural systems mediating conditioned fear, little is known about the neural mechanisms underlying conditioned inhibitors of fear (or safety signals). The present series of experiments examined the involvement of the nucleus accumbens (NAC) in mediating the effects of safety signals on behavior using a conditioned inhibition of fear-potentiated startle paradigm. Neither increasing dopaminergic nor decreasing glutamatergic function in the NAC altered the magnitude of conditioned fear or conditioned inhibition of fear in rats. Furthermore, large pre- or post-training electrolytic lesions of the NAC did not affect acquisition or expression of fear-potentiated startle or conditioned inhibition of fear-potentiated startle. Taken together, these data suggest that the NAC is not critically involved in the acquisition or expression of fear-potentiated startle or conditioned inhibition of fear-potentiated startle. Previous research has implicated the NAC in 'reward-attenuated startle' in which presentation of a stimulus paired with food decreased startle responding. The present results, therefore, indicate important neural dissociations between the processing of appetitive and safety signals, even though behavioral studies and learning theories have suggested that these two forms of learning share some commonalities.
Sheena A Josselyn; William A Falls; Jonathan C Gewirtz; Paul Pistell; Michael Davis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  30     ISSN:  0893-133X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-20     Completed Date:  2005-01-26     Revised Date:  2011-05-18    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17-26     Citation Subset:  IM    
Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT, USA.
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MeSH Terms
6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
Acoustic Stimulation
Amphetamine / pharmacology
Behavior, Animal / physiology*
Cerebrovascular Circulation / drug effects
Conditioning (Psychology) / physiology
Dopamine / physiology
Dopamine Uptake Inhibitors / pharmacology
Excitatory Amino Acid Antagonists / pharmacology
Fear / physiology*
Nucleus Accumbens / blood supply,  physiology*
Rats, Sprague-Dawley
Receptors, AMPA / antagonists & inhibitors
Startle Reaction / physiology
Grant Support
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; 0/Excitatory Amino Acid Antagonists; 0/Receptors, AMPA; 115066-14-3/6-Cyano-7-nitroquinoxaline-2,3-dione; 300-62-9/Amphetamine

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