Document Detail


The nucleotide sequence of rabbit liver transferrin cDNA.
MedLine Citation:
PMID:  2054387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cDNA sequence of rabbit liver transferrin has been determined. The largest cDNA was 2279 base pairs (bp) in size and encoded 694 amino acids consisting of a putative 19 amino acid signal peptide and 675 amino acids of plasma transferrin. The deduced amino acid sequence of rabbit liver transferrin shares 78.5% identity with human liver transferrin and 69.1% and 44.8% identity with porcine and Xenopus transferrins, respectively. At the amino acid level, vertebrate transferrins share 26.4% identity and 56.5% similarity. The most conserved regions correspond to the iron ligands and the anion binding region. Optimal alignment of transferrin sequences required the insertion of a number of gaps in the region corresponding to the N-lobe. In addition, the N-lobes of transferrins share less amino acid sequence similarity than the C-lobes.
Authors:
D K Banfield; B K Chow; W D Funk; K A Robertson; T M Umelas; R C Woodworth; R T MacGillivray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1089     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-31     Completed Date:  1991-07-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  262-5     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of British Columbia, Vancouver, Canada.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/X58533
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
DNA / genetics*
Humans
Iron Chelating Agents / metabolism
Liver / metabolism*
Molecular Sequence Data
Rats
Sequence Homology, Nucleic Acid
Swine
Transferrin / genetics*
Xenopus
Grant Support
ID/Acronym/Agency:
DK21739/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Iron Chelating Agents; 11096-37-0/Transferrin; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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