Document Detail

The nucleotide sequence of a human cDNA encoding the highly conserved nucleolar phosphoprotein B23.
MedLine Citation:
PMID:  2775293     Owner:  NLM     Status:  MEDLINE    
A cDNA clone containing the complete coding sequence for the human nucleolar phosphoprotein B23 was isolated from a Burkitt's lymphoma cDNA library by immunoscreening with human autoantibodies. The B23 clone contained a 1.3 kb cDNA insert encoding a polypeptide of 294 amino acids with a predicted molecular mass of 32,539 daltons. The deduced B23 amino acid sequence contained 2 acidic domains rich in aspartic and glutamic acid, a feature shared by a number of nuclear and nucleolar proteins. The human B23 amino acid sequence showed 98% homology with rat B23 and 68% homology with the Xenopus laevis nucleolar phosphoprotein, NO38 showing that the primary structure of B23 is highly conserved among these species.
X Z Li; L J McNeilage; S Whittingham
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  163     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-10-06     Completed Date:  1989-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  72-8     Citation Subset:  IM    
Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Cell Nucleolus / physiology*
Cloning, Molecular
DNA / genetics
Molecular Sequence Data
Nuclear Proteins / genetics*
Reg. No./Substance:
0/Nuclear Proteins; 117896-08-9/nucleophosmin; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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