| The nucleotide sequence of a human cDNA encoding the highly conserved nucleolar phosphoprotein B23. | |
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MedLine Citation:
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PMID: 2775293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A cDNA clone containing the complete coding sequence for the human nucleolar phosphoprotein B23 was isolated from a Burkitt's lymphoma cDNA library by immunoscreening with human autoantibodies. The B23 clone contained a 1.3 kb cDNA insert encoding a polypeptide of 294 amino acids with a predicted molecular mass of 32,539 daltons. The deduced B23 amino acid sequence contained 2 acidic domains rich in aspartic and glutamic acid, a feature shared by a number of nuclear and nucleolar proteins. The human B23 amino acid sequence showed 98% homology with rat B23 and 68% homology with the Xenopus laevis nucleolar phosphoprotein, NO38 showing that the primary structure of B23 is highly conserved among these species. |
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Authors:
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X Z Li; L J McNeilage; S Whittingham |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 163 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-10-06 Completed Date: 1989-10-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 72-8 Citation Subset: IM |
Affiliation:
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Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Victoria, Australia. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/M28699 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Base Sequence Cell Nucleolus / physiology* Cloning, Molecular DNA / genetics Humans Molecular Sequence Data Nuclear Proteins / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Nuclear Proteins; 117896-08-9/nucleophosmin; 9007-49-2/DNA |
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