Document Detail

The nucleolus of the maternal gamete is essential for life.
MedLine Citation:
PMID:  18536024     Owner:  NLM     Status:  MEDLINE    
The mammalian oocyte is a round cell arrested at prophase I of meiosis. It is characterized by the presence of a large nucleus, called the germinal vesicle, in the middle of which is the nucleolus. Before it can be fertilized, the oocyte must resume meiosis, enter metaphase II and be ovulated. The nucleolus is dissolved during this process. However, the nucleoli of the male and female pronuclei in the zygote are both of maternal origin. A recent paper1 demonstrates that the maternal nucleolus, together with other nucleoplasmic elements, is essential for early embryonic development. These nucleolar and nucleoplasmic factors remain undetermined.
Brigitte Lefèvre
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  30     ISSN:  1521-1878     ISO Abbreviation:  Bioessays     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-11     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  United States    
Other Details:
Languages:  eng     Pagination:  613-6     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley Periodicals, Inc.
UMR 566, INSERM, CEA/IRCM/SECR/LGAG, University Paris 7, University Paris 11, Fontenay-aux-Roses, F-92260, France.
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MeSH Terms
Cell Nucleolus / metabolism*
Cloning, Organism*
Embryo, Mammalian / cytology,  physiology*
Meiosis / physiology
Nuclear Transfer Techniques
Oocytes / cytology,  physiology
Stem Cells / cytology

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