Document Detail

The nuclear lamins: flexibility in function.
MedLine Citation:
PMID:  23212477     Owner:  NLM     Status:  Publisher    
The nuclear lamina is an important structural determinant for the nuclear envelope as a whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear envelope proteins. The major components of the lamina are the A-type and B-type lamins, which are members of the intermediate filament protein family. Whereas the expression of A-type lamins is developmentally regulated, B-type lamins, as a class, are found in all cells. The association of B-type lamins with many aspects of nuclear function has led to the view that these are essential proteins, and there is growing evidence suggesting that they regulate cellular senescence. However, B-type lamins are dispensable in certain cell types in vivo, and neither A-type nor B-type lamins may be required in early embryos or embryonic stem cells. The picture that is beginning to emerge is of a complex network of interactions at the nuclear periphery that may be defined by cell- and tissue-specific functions.
Brian Burke; Colin L Stewart
Related Documents :
24768297 - Ptenα, a pten isoform translated through alternative initiation, regulates mitochondri...
7601127 - Over-production, purification and properties of the uridine-diphosphate-n-acetylmuramat...
24990967 - A fly trap mechanism provides sequence-specific rna recognition by cpeb proteins.
24884657 - Characterization of a new mouse p53 variant: loss-of-function and gain-of-function.
24204967 - Mmi1, the yeast homologue of mammalian tctp, associates with stress granules in heat-sh...
15803647 - Cellular localization of d-lactate dehydrogenase and nadh oxidase from archaeoglobus fu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-05
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  -     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute of Medical Biology, 8A Biomedical Grove, Immunos 06-06, Singapore 138648.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  New insights into the regulation and cellular functions of the ARP2/3 complex.
Next Document:  Re-Re bond breaking of (?-H)(3)Re(3)(CO)(11)(NCMe) upon reaction with PPh(2)(o-C(6)H(4))(CH(2)NMeCH)...