| The nuclear envelope: emerging roles in development and disease. | |
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MedLine Citation:
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PMID: 11766874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The chromosomes of eukaryotic cells are separated from the cytoplasm by the nuclear envelope. The nuclear envelope includes two riveted membranes, plus embedded pore complexes that mediate nuclear import and export. In this sense, the nuclear envelope is truly a border zone. However, the envelope also links directly to chromosomes, and anchors two major infrastructures--the nuclear lamina and Tpr filaments--to the nuclear perimeter. Proteins of the nuclear envelope mediate a variety of fundamental activities, including DNA replication, gene expression and silencing, chromatin organization, cell division, apoptosis, sperm nuclear remodeling, the behavior of pronuclei, cell fate determination, nuclear migration and cell polarity. Furthermore, mutations in nuclear lamins and lamin-binding proteins cause tissue-specific inherited diseases. This special issue of Cell and Molecular Life Sciences is devoted to recent major advances in the characterization of nuclear envelope proteins and their roles. We offer here an overview of the topics covered in this issue of CMLS, and also discuss the emerging recognition that the nuclear envelope is an organelle critical for a wide range of genetic and developmental activity in multicellular organisms. |
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Authors:
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M F Wolfner; K L Wilson |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 58 ISSN: 1420-682X ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-12-19 Completed Date: 2002-01-10 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1737-40 Citation Subset: IM |
Affiliation:
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Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853-2703, USA. mfw5@cornell.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology Cell Nucleus / metabolism* Humans Lamins Muscular Dystrophies / physiopathology Nuclear Envelope / chemistry, physiology* Nuclear Proteins / genetics, metabolism* ran GTP-Binding Protein / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Lamins; 0/Nuclear Proteins; EC 3.6.5.2/ran GTP-Binding Protein |
| Comments/Corrections | |
Comment On:
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Cell Mol Life Sci. 2001 Nov;58(12-13):1781-9
[PMID:
11766879
]
Cell Mol Life Sci. 2001 Nov;58(12-13):1774-80 [PMID: 11766878 ] Cell Mol Life Sci. 2001 Nov;58(12-13):1748-57 [PMID: 11766876 ] Cell Mol Life Sci. 2001 Nov;58(12-13):1758-65 [PMID: 11767745 ] Cell Mol Life Sci. 2001 Nov;58(12-13):1741-7 [PMID: 11766875 ] Cell Mol Life Sci. 2001 Nov;58(12-13):1766-73 [PMID: 11766877 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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