Document Detail

The nuclear-encoded inteins of fungi.
MedLine Citation:
PMID:  17046294     Owner:  NLM     Status:  MEDLINE    
An intein is a protein sequence embedded within a precursor protein that is excised during protein maturation. Inteins were first found encoded in the VMA gene of Saccharomyces cerevisiae. Subsequently, they have been found in diverse organisms (eukaryotes, archaea, eubacteria and viruses). The VMA intein has been found in various saccharomycete yeasts but not in other fungi. Different inteins have now been found widely in the fungi (ascomycetes, basidiomycetes, zygomycetes and chytrids) and in diverse proteins. A protein distantly related to inteins, but closely related to metazoan hedgehog proteins, has been described from Glomeromycota. Many of the newly described inteins contain homing endonucleases and some of these are apparently active. The enlarged fungal intein data set permits insight into the evolution of inteins, including the role of horizontal transfer in their persistence. The diverse fungal inteins provide a resource for biotechnology using their protein splicing or homing endonuclease capabilities.
Russell T M Poulter; Timothy J D Goodwin; Margaret I Butler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-10-13
Journal Detail:
Title:  Fungal genetics and biology : FG & B     Volume:  44     ISSN:  1087-1845     ISO Abbreviation:  Fungal Genet. Biol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-05     Completed Date:  2007-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607601     Medline TA:  Fungal Genet Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-79     Citation Subset:  IM    
Department of Biochemistry, University of Otago, Dunedin, New Zealand.
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MeSH Terms
Amino Acid Sequence
Cell Nucleus / genetics
Fungal Proteins / genetics
Genome, Fungal / genetics*
Inteins / genetics*
Molecular Sequence Data
Protein Splicing / genetics
Sequence Homology, Amino Acid
Reg. No./Substance:
0/Fungal Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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