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T(1;21;8)(p34;q22;q22): a novel variant of t(8;21) in acute myeloblastic leukemia with maturation.
MedLine Citation:
PMID:  20949334     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The complex variants of t(8;21) involving chromosomes 8 and 21 as well as another chromosome account for approximately 3% of acute myeloid leukemia patients. We report here a 30-year-old male patient with AML-M2. Fluorescence in situ hybridization analysis using dual-color fluorescence ETO and AML1 probes located at 8q22 and 21q22 respectively showed an AML1/ETO fusion signal on the derivative chromosome 8. Whole chromosome painting probes were used for chromosome 1, 8 and 21 and revealed a three-way translocation (1;21;8)(p34 ~ p35;q22;q22). Involvement of chromosome region 1p34 has never been reported earlier, although region 1p35 as a variant in AML with t(8;21) has been reported with an AML1/ETO fusion signal on the 1p35 rather than der(8). In conclusion, combining conventional karyotype, FISH or RT-PCR analyses are a rational strategy for the identification of the complex variants of t(8;21) translocation which could be critical events responsible for leukemogenesis.
Authors:
Abir Gmidène; Rim Frikha; Hlima Sennana; Hatem Elghezal; Moez Elloumi; Ali Saad
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Publication Detail:
Type:  Journal Article     Date:  2010-10-14
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  28 Suppl 1     ISSN:  1559-131X     ISO Abbreviation:  Med. Oncol.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-12     Citation Subset:  IM    
Affiliation:
Laboratoire de Cytogénétique et de Biologie de la Reproduction, Hôpital Farhat Hached, Avenue Ibn Eljazzar, 4000, Sousse, Tunisie, gmidene_abir@yahoo.fr.
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