Document Detail


A novel transformation of 13-LS-hydroperoxy-9,11-octadecadienoic acid.
MedLine Citation:
PMID:  6860694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
13-LS-Hydroperoxy-9,11-octadecadienoic acid (13-HPOD) was incubated with human hemoglobin. Apart from monoketo-, monohydroxy- as well as a number of hydroxy-epoxy acid derivatives earlier identified (Hamberg, M. (1975) Lipids 10, 87-92) a small conversion (1-2%) of 13-HPOD into 8-LR, 13-LS- and 8-DS, 13-LS-dihydroxy-9trans,11trans-octadecadienoic acids was demonstrated. An unstable intermediate, i.e., 12,13-epoxy-8,10-octadecadienoic acid, was detected in the conversion of 13-HPOD into the two dihydroxy-octadecadienoates by trapping experiments. It was concluded that compounds structurally related to the leukotrienes may be formed nonenzymatically from 13-HPOD.
Authors:
M Hamberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  752     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  191-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biotransformation
Chemical Phenomena
Chemistry
Gas Chromatography-Mass Spectrometry
Hemoglobins / metabolism*
Humans
Linoleic Acids / biosynthesis*,  metabolism*
Lipid Peroxides*
Stereoisomerism
Chemical
Reg. No./Substance:
0/8,13-dihydroxy-9,11-octadecadienoic acid; 0/Hemoglobins; 0/Linoleic Acids; 0/Lipid Peroxides; 23017-93-8/13-hydroperoxy-9,11-octadecadienoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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