Document Detail


A novel textured surface for blood-contact.
MedLine Citation:
PMID:  10353649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood-contacting surface modifications aimed at reduction of thromboembolic complications have included the texturing of surfaces so as to promote the formation of a stable pseudo-neointima. A technique has been developed whereby a textured surface consisting of regularly spaced micro-fibres was produced on a smooth base plane. Polyurethane vascular patches with and without the textured luminal surface were fabricated and implanted bilaterally in ovine carotid arteries for 1- and 3-week implantation periods (n = 6 per period). One of 6 arteries with textured patches in the 1-week group was occluded. All other arteries were patent. At 1 week, all patent textured patches had adherent thrombus covering the entire patch surface. By 3 weeks, the thrombus had organised to form a stable pseudo-neointima. Non-textured patches at 1 week had only partial surface coverage of thrombus. At 3 weeks, 4 of 6 non-textured patches had significant red thrombus in the lumen. At 3 weeks, there was also evidence of cellular migration from artery onto both textured and non-textured patches. These findings suggest that the major role of the textured surface was as a promoter of a stabilised thrombus base onto which subsequent cellular migration and tissue healing occurred more rapidly than onto a smooth polyurethane surface.
Authors:
N Fujisawa; L A Poole-Warren; J C Woodard; C D Bertram; K Schindhelm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomaterials     Volume:  20     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-08-10     Completed Date:  1999-08-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  955-62     Citation Subset:  IM    
Affiliation:
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia. n.fujisawa@unsw.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials*
Blood*
Blood Vessel Prosthesis*
Carotid Arteries / surgery
Male
Materials Testing
Microscopy, Electron, Scanning
Polyurethanes
Sheep
Surface Properties
Thromboembolism / prevention & control
Time Factors
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Polyurethanes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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