| A novel textured surface for blood-contact. | |
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MedLine Citation:
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PMID: 10353649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood-contacting surface modifications aimed at reduction of thromboembolic complications have included the texturing of surfaces so as to promote the formation of a stable pseudo-neointima. A technique has been developed whereby a textured surface consisting of regularly spaced micro-fibres was produced on a smooth base plane. Polyurethane vascular patches with and without the textured luminal surface were fabricated and implanted bilaterally in ovine carotid arteries for 1- and 3-week implantation periods (n = 6 per period). One of 6 arteries with textured patches in the 1-week group was occluded. All other arteries were patent. At 1 week, all patent textured patches had adherent thrombus covering the entire patch surface. By 3 weeks, the thrombus had organised to form a stable pseudo-neointima. Non-textured patches at 1 week had only partial surface coverage of thrombus. At 3 weeks, 4 of 6 non-textured patches had significant red thrombus in the lumen. At 3 weeks, there was also evidence of cellular migration from artery onto both textured and non-textured patches. These findings suggest that the major role of the textured surface was as a promoter of a stabilised thrombus base onto which subsequent cellular migration and tissue healing occurred more rapidly than onto a smooth polyurethane surface. |
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Authors:
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N Fujisawa; L A Poole-Warren; J C Woodard; C D Bertram; K Schindhelm |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomaterials Volume: 20 ISSN: 0142-9612 ISO Abbreviation: Biomaterials Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-08-10 Completed Date: 1999-08-10 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 955-62 Citation Subset: IM |
Affiliation:
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Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia. n.fujisawa@unsw.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials* Blood* Blood Vessel Prosthesis* Carotid Arteries / surgery Male Materials Testing Microscopy, Electron, Scanning Polyurethanes Sheep Surface Properties Thromboembolism / prevention & control Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Polyurethanes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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