| A novel synthetic vitamin D3 analogue, 2-beta-(3-hydroxypropoxy)-calcitriol (ED-71): its biological activities and pharmacological effects on calcium metabolism. | |
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MedLine Citation:
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PMID: 1800002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel vitamin D3 analogue, [2 beta-(3-hydroxypropoxy)-calcitriol: ED-71] showed a similar Ca-regulating activity as calcitriol in the in vivo and in vitro Ca mobilization test and ex vivo intestinal Ca absorption assay using vitamin D-deficient rats. The differentiation-inducing activity of ED-71 in mouse myeloid leukemia cell line (WEHI-3 cell) was slightly less than that of calcitriol. ED-71 distributes predominantly in plasma as an intact form and its half-life plasma was twice as long as that of calcitriol. Further study revealed that the higher binding potency of ED-71 to plasma-specific vitamin D-binding protein (DBP) compared with that of calcitriol accounts for its stability in the blood circulation. The pharmacological effect of ED-71 for the animal models with osteoporosis seemed to be better than that calcitriol. These results suggest that ED-71 should become a valuable therapeutic long-acting drug for patients with osteoporosis. |
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Authors:
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T Okano; N Tsugawa; S Masuda; A Takeuchi; T Kobayashi; Y Nishii |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Contributions to nephrology Volume: 91 ISSN: 0302-5144 ISO Abbreviation: Contrib Nephrol Publication Date: 1991 |
Date Detail:
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Created Date: 1992-04-21 Completed Date: 1992-04-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7513582 Medline TA: Contrib Nephrol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 116-22 Citation Subset: IM |
Affiliation:
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Department of Hygienic Sciences, Kobe Women's College of Pharmacy, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcitriol / analogs & derivatives*, metabolism, pharmacology Calcium / metabolism* Male Osteoporosis / metabolism Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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104121-92-8/2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3; 32222-06-3/Calcitriol; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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