Document Detail

A novel synthetic vitamin D3 analogue, 2-beta-(3-hydroxypropoxy)-calcitriol (ED-71): its biological activities and pharmacological effects on calcium metabolism.
MedLine Citation:
PMID:  1800002     Owner:  NLM     Status:  MEDLINE    
A novel vitamin D3 analogue, [2 beta-(3-hydroxypropoxy)-calcitriol: ED-71] showed a similar Ca-regulating activity as calcitriol in the in vivo and in vitro Ca mobilization test and ex vivo intestinal Ca absorption assay using vitamin D-deficient rats. The differentiation-inducing activity of ED-71 in mouse myeloid leukemia cell line (WEHI-3 cell) was slightly less than that of calcitriol. ED-71 distributes predominantly in plasma as an intact form and its half-life plasma was twice as long as that of calcitriol. Further study revealed that the higher binding potency of ED-71 to plasma-specific vitamin D-binding protein (DBP) compared with that of calcitriol accounts for its stability in the blood circulation. The pharmacological effect of ED-71 for the animal models with osteoporosis seemed to be better than that calcitriol. These results suggest that ED-71 should become a valuable therapeutic long-acting drug for patients with osteoporosis.
T Okano; N Tsugawa; S Masuda; A Takeuchi; T Kobayashi; Y Nishii
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contributions to nephrology     Volume:  91     ISSN:  0302-5144     ISO Abbreviation:  Contrib Nephrol     Publication Date:  1991  
Date Detail:
Created Date:  1992-04-21     Completed Date:  1992-04-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7513582     Medline TA:  Contrib Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  116-22     Citation Subset:  IM    
Department of Hygienic Sciences, Kobe Women's College of Pharmacy, Japan.
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MeSH Terms
Calcitriol / analogs & derivatives*,  metabolism,  pharmacology
Calcium / metabolism*
Osteoporosis / metabolism
Rats, Inbred Strains
Reg. No./Substance:
104121-92-8/2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3; 32222-06-3/Calcitriol; 7440-70-2/Calcium

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