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A novel synthesis of 1-aryl-3-piperidone derivatives.
MedLine Citation:
PMID:  23316094     Owner:  NLM     Status:  Publisher    
A novel method to construct the 1-aryl-3-piperidone scaffold is described here. Starting from 3,5-dichloroaniline, a seven-step synthesis, without the use of protecting groups, generates the desired 3-piperidone ring in an overall yield of 30% through a key Morita-Baylis-Hillman reaction and ring-closing metathesis, providing easy access to diverse and useful heterocycles.
Yinan Zhang; Richard B Silverman
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Publication Detail:
Journal Detail:
Title:  Tetrahedron letters     Volume:  54     ISSN:  0040-4039     ISO Abbreviation:  Tetrahedron Lett.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984819R     Medline TA:  Tetrahedron Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  573-575     Citation Subset:  -    
Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Design, Northwestern University, Evanston, Illinois 60208-3113 USA.
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