Document Detail


A novel subcutaneous controlled-release amoxicillin degradable implant for extended-interval administration in veterinary medicine.
MedLine Citation:
PMID:  21198679     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Horwitz, E., Kagan, L., Avni-Magen, N., Daryi, D., Gati, I., Hoffman, A., Friedman, M., Lavy, E. A novel subcutaneous controlled-release amoxicillin degradable implant for extended-interval administration in veterinary medicine. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2010.01256.x. Dosage forms of antimicrobials play a critical role in facilitating the attainment of pharmacokinetic-pharmacodynamic (PK-PD) targets as well as adherence in both veterinary and human medicine. The purpose of this study was to develop and evaluate a controlled-release subcutaneous amoxicillin implant for single-dose therapy of large ruminants such as goats, sheep, and deer. The degradable implant, designed to attain PK-PD targets following single administration, was evaluated for amoxicillin release rate and time-concentration profile. In vitro release studies demonstrated constant-rate release of approximately 40% of amoxicillin content within 96 h. In an in vivo study in goats, serving as a model for target animals, a serum concentration of approximately 0.4 mg/L was achieved within 8 h of implant insertion and maintained for >6 days. In comparison, in control goats given a standard single intramuscular amoxicillin dose of 15 mg/kg, amoxicillin peaked at 1.2 mg/L after 1 h, rapidly dropping to below detection level at 8 h. These results suggest that the proposed implant offers a unique modality for animal caregivers to conveniently administer a full antimicrobial course following a single dose of an efficient PK-PD-optimized dosage form. Furthermore, modifications of implant composition may allow for tailoring of its characteristics to various PK, PD, microbiological, and clinical requirements.
Authors:
E Horwitz; L Kagan; N Avni-Magen; D Daryi; I Gati; A Hoffman; M Friedman; E Lavy
Related Documents :
20636729 - Cement thickness at implant-supported single-tooth lava assemblies: a scanning electron...
16958689 - Survival and complication rates of combined tooth-implant-supported fixed partial dentu...
9028219 - Multiple implants for first molar prosthodontics.
18309609 - Marginal fit and microgaps of implant-abutment interface with internal anti-rotation co...
11450419 - Replacement therapy and the immediate post-extraction dental implant.
2012669 - Considerations for fabrication of implant-supported posterior restorations.
8506529 - Impaired endothelial prostacyclin production of the canine vein graft in a poor distal ...
11895279 - Smoking and complications of endosseous dental implants.
8568099 - The edentulous predicament. i: a prospective study of the effectiveness of implant-supp...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-28
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  -     ISSN:  1365-2885     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Affiliation:
Pharmaceutics Department, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel Tisch Family Zoological Gardens, Jerusalem, Israel School of Veterinary Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Novel gastroretentive controlled-release drug delivery system for amoxicillin therapy in veterinary ...
Next Document:  Plasma pharmacokinetics of abamectin in fallow deer (Cervus dama dama) following subcutaneous admini...