Document Detail

A novel subcutaneous controlled-release amoxicillin degradable implant for extended-interval administration in veterinary medicine.
MedLine Citation:
PMID:  21198679     Owner:  NLM     Status:  Publisher    
Horwitz, E., Kagan, L., Avni-Magen, N., Daryi, D., Gati, I., Hoffman, A., Friedman, M., Lavy, E. A novel subcutaneous controlled-release amoxicillin degradable implant for extended-interval administration in veterinary medicine. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2010.01256.x. Dosage forms of antimicrobials play a critical role in facilitating the attainment of pharmacokinetic-pharmacodynamic (PK-PD) targets as well as adherence in both veterinary and human medicine. The purpose of this study was to develop and evaluate a controlled-release subcutaneous amoxicillin implant for single-dose therapy of large ruminants such as goats, sheep, and deer. The degradable implant, designed to attain PK-PD targets following single administration, was evaluated for amoxicillin release rate and time-concentration profile. In vitro release studies demonstrated constant-rate release of approximately 40% of amoxicillin content within 96 h. In an in vivo study in goats, serving as a model for target animals, a serum concentration of approximately 0.4 mg/L was achieved within 8 h of implant insertion and maintained for >6 days. In comparison, in control goats given a standard single intramuscular amoxicillin dose of 15 mg/kg, amoxicillin peaked at 1.2 mg/L after 1 h, rapidly dropping to below detection level at 8 h. These results suggest that the proposed implant offers a unique modality for animal caregivers to conveniently administer a full antimicrobial course following a single dose of an efficient PK-PD-optimized dosage form. Furthermore, modifications of implant composition may allow for tailoring of its characteristics to various PK, PD, microbiological, and clinical requirements.
E Horwitz; L Kagan; N Avni-Magen; D Daryi; I Gati; A Hoffman; M Friedman; E Lavy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-28
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  -     ISSN:  1365-2885     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Pharmaceutics Department, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel Tisch Family Zoological Gardens, Jerusalem, Israel School of Veterinary Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
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