| A novel role for cardiac neural crest in heart development. | |
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MedLine Citation:
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PMID: 10881754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well known that cardiac neural crest participates in development of the cardiac outflow septation and patterning of the great arteries. Less well known is that ablation of the cardiac neural crest leads to a primary myocardial dysfunction. Recent data suggests that the myocardial dysfunction occurs because of the absence of an interaction of neural crest and pharyngeal endoderm to alter signaling from the endoderm. Continuation of an FGF-like signal from the endoderm past a precise time in development appears to be detrimental to myocardial maturation. |
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Authors:
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M Farrell; K Waldo; Y X Li; M L Kirby |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 9 ISSN: 1050-1738 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 2000-08-09 Completed Date: 2000-08-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 214-20 Citation Subset: IM |
Affiliation:
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Developmental Biology Program, Medical College of Georgia, Augusta 30912-2640, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chick Embryo Disease Models, Animal Heart / embryology* Heart Defects, Congenital / embryology, pathology Hemodynamics Neural Crest / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HD16057/HD/NICHD NIH HHS; HL36059/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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