Document Detail

A novel role for cardiac neural crest in heart development.
MedLine Citation:
PMID:  10881754     Owner:  NLM     Status:  MEDLINE    
It is well known that cardiac neural crest participates in development of the cardiac outflow septation and patterning of the great arteries. Less well known is that ablation of the cardiac neural crest leads to a primary myocardial dysfunction. Recent data suggests that the myocardial dysfunction occurs because of the absence of an interaction of neural crest and pharyngeal endoderm to alter signaling from the endoderm. Continuation of an FGF-like signal from the endoderm past a precise time in development appears to be detrimental to myocardial maturation.
M Farrell; K Waldo; Y X Li; M L Kirby
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  9     ISSN:  1050-1738     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-08-09     Completed Date:  2000-08-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  214-20     Citation Subset:  IM    
Developmental Biology Program, Medical College of Georgia, Augusta 30912-2640, USA.
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MeSH Terms
Chick Embryo
Disease Models, Animal
Heart / embryology*
Heart Defects, Congenital / embryology,  pathology
Neural Crest / physiology*
Grant Support

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