| A novel respiratory motion compensation strategy combining gated beam delivery and mean target position concept - A compromise between small safety margins and long duty cycles. | |
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MedLine Citation:
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PMID: 21354640 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To evaluate a novel respiratory motion compensation strategy combining gated beam delivery with the mean target position (MTP) concept for pulmonary stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS: Four motion compensation strategies were compared for 10 targets with motion amplitudes between 6mm and 31mm: the internal target volume concept (plan(ITV)); the MTP concept where safety margins were adapted based on 4D dose accumulation (plan(MTP)); gated beam delivery without margins for motion compensation (plan(gated)); a novel approach combining gating and the MTP concept (plan(gated&MTP)). RESULTS: For 5/10 targets with an average motion amplitude of 9mm, the differences in the mean lung dose (MLD) between plan(gated) and plan(MTP) were <10%. For the other 5/10 targets with an average motion amplitude of 19mm, gating with duty cycles between 87.5% and 75% reduced the residual target motion to 12mm on average and 2mm safety margins were sufficient for dosimetric compensation of this residual motion in plan(gated&MTP). Despite significantly shorter duty cycles, plan(gated) reduced the MLD by <10% compared to plan(gated&MTP). The MLD was increased by 18% in plan(MTP) compared to that of plan(gated&MTP). CONCLUSIONS: For pulmonary targets with motion amplitudes >10-15mm, the combination of gating and the MTP concept allowed small safety margins with simultaneous long duty cycles. |
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Authors:
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Matthias Guckenberger; Anthony Kavanagh; Steve Webb; Michael Brada |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-25 |
Journal Detail:
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Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Volume: - ISSN: 1879-0887 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8407192 Medline TA: Radiother Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Radiation Oncology, University Hospital Wuerzburg, Germany; Academic Unit of Radiotherapy & Oncology, The Royal Marsden NHS Foundation Trust, Surrey, UK; The Institute of Cancer Research and Lung Unit, The Royal Marsden NHS Foundation Trust, Surrey, UK. |
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