Document Detail


The novel quantitative trait locus GL3.1 controls rice grain size and yield by regulating Cyclin-T1;3.
MedLine Citation:
PMID:  23147796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased crop yields are required to support rapid population growth worldwide. Grain weight is a key component of rice yield, but the underlying molecular mechanisms that control it remain elusive. Here, we report the cloning and characterization of a new quantitative trait locus (QTL) for the control of rice grain length, weight and yield. This locus, GL3.1, encodes a protein phosphatase kelch (PPKL) family - Ser/Thr phosphatase. GL3.1 is a member of the large grain WY3 variety, which is associated with weaker dephosphorylation activity than the small grain FAZ1 variety. GL3.1-WY3 influences protein phosphorylation in the spikelet to accelerate cell division, thereby resulting in longer grains and higher yields. Further studies have shown that GL3.1 directly dephosphorylates its substrate, Cyclin-T1;3, which has only been rarely studied in plants. The downregulation of Cyclin-T1;3 in rice resulted in a shorter grain, which indicates a novel function for Cyclin-T in cell cycle regulation. Our findings suggest a new mechanism for the regulation of grain size and yield that is driven through a novel phosphatase-mediated process that affects the phosphorylation of Cyclin-T1;3 during cell cycle progression, and thus provide new insight into the mechanisms underlying crop seed development. We bred a new variety containing the natural GL3.1 allele that demonstrated increased grain yield, which indicates that GL3.1 is a powerful tool for breeding high-yield crops.
Authors:
Peng Qi; You-Shun Lin; Xian-Jun Song; Jin-Bo Shen; Wei Huang; Jun-Xiang Shan; Mei-Zhen Zhu; Liwen Jiang; Ji-Ping Gao; Hong-Xuan Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-13
Journal Detail:
Title:  Cell research     Volume:  22     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-04     Completed Date:  2013-05-16     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1666-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alleles
Cell Division
Cloning, Molecular
Cyclin T / genetics,  metabolism*
Down-Regulation
Genes, Plant
Oryza sativa / genetics,  growth & development,  metabolism*
Phosphorylation
Plant Proteins / genetics,  metabolism*
Plants, Genetically Modified / genetics,  metabolism
Protein-Serine-Threonine Kinases / genetics,  metabolism*
Quantitative Trait Loci*
Seeds / genetics,  metabolism
Chemical
Reg. No./Substance:
0/Cyclin T; 0/Plant Proteins; EC 2.7.11.1/Protein-Serine-Threonine Kinases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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