| A novel potentiometric method for the determination of real crosslinking ratio of poly(aspartic acid) gels. | |
| | |
MedLine Citation:
|
PMID: 19761876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In order to obtain nontoxic functional polymer gels for biomedical applications, chemically crosslinked poly(aspartic acid) gels have been prepared using 1,4-diaminobutane as crosslinker. The presence of COOH and amino groups on the network chains renders these gels pH sensitive. Due to the specific hydrophobic-hydrophilic balance, these gels show a significant volume transition at a well-defined pH close to the pK value of uncrosslinked poly(aspartic acid). Since the magnitude of volume change critically depends on the degree of crosslinking, it is an important task to determine the topological characteristics of these networks. A novel method based on potentiometric acid-base titration has been developed to assess the crosslinking ratio, excluding physical crosslinks and entanglements. It turned out that only 25% of all crosslinker molecules forms real crosslinks between the poly(aspartic acid) chains; the rest react with one of its functional groups and forms short pendant side chains. At a nominal crosslinking ratio of 0.1, the number average molecular mass between crosslinks is found to be M(c) = 2300. |
| | |
Authors:
|
Vikt?ria Torma; Tam?s Gyenes; Zolt?n Szak?cs; Mikl?s Zr?nyi |
Related Documents
:
|
20420886 - Preparation and pharmacodynamics of stearic acid and poly (lactic-co-glycolic acid) gra... 10530196 - Crystal growth technique for composite resin bonding. a sem study. 15356866 - Titration of poly(da-dt) . poly(da-dt) in solution at variable nacl concentration. 1058236 - Composition and structure of dental enamel: elemental composition and crystalline struc... 15978626 - Effects of amino acids from selenium-rich silkworm pupas on human hepatoma cells. 11885776 - Quantification of free fatty acids in human cerebrospinal fluid. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-15 |
Journal Detail:
|
Title: Acta biomaterialia Volume: 6 ISSN: 1878-7568 ISO Abbreviation: Acta Biomater Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-01 Completed Date: 2010-03-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101233144 Medline TA: Acta Biomater Country: England |
Other Details:
|
Languages: eng Pagination: 1186-90 Citation Subset: IM |
Copyright Information:
|
Copyright 2010. Published by Elsevier Ltd. |
Affiliation:
|
Department of Pharmaceutics, Faculty of Pharmacy, Semmelweis University, Hogyes Endre u. 7, H-1092 Budapest, Hungary. viki.torma@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biocompatible Materials
/
chemistry* Cross-Linking Reagents / chemistry* Electrochemistry / methods* Gels / chemistry* Materials Testing / methods* Peptides / chemistry* |
| Chemical | |
Reg. No./Substance:
|
0/Biocompatible Materials; 0/Cross-Linking Reagents; 0/Gels; 0/Peptides; 26063-13-8/polyaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic si...
Next Document: Yeast cultures with UCP1 uncoupling activity as a heating device.