Document Detail

A novel porcine model for right ventricular dilatation by external suture plication of the pulmonary valve leaflets--practical and reproducible.
MedLine Citation:
PMID:  20197345     Owner:  NLM     Status:  MEDLINE    
The right ventricle (RV) tolerates acute pulmonary valvular regurgitation fairly well, however, in the long-term dilatation and failure often ensues. There is little known of the structural and functional myocardial alterations following this pathophysiology, and therefore animal models are sought. We aimed to develop an animal experimental model for RV dilatation emphasizing feasibility, reproducibility and human compatibility. Free pulmonary valve insufficiency and RV dilatation were created with a novel external suture plication technique in nine 5 kg piglets. Six matched animals served as controls. After 10 weeks cardiac dimensions and physiology were assessed with in vivo cardiovascular MRI and conductance technique. RV end-diastolic volume increased 31% in the intervention group (P=0.03). The regurgitation fraction was 37% in the intervention group compared to -2% in controls (P<0.001). Conductance measurements showed preserved RV contractile function, but significant left ventricular diastolic impairment. This study is the first to show that pulmonary valve regurgitation, RV dilatation and functional impairment can be achieved by external leaflet plication. Compared to known methods, the advantages of this model are: 1) no induction of stenosis over time, 2) no risk of stent migration, and 3) very simple and reproducible.
Peter Agger; Janus Adler Hyldebrandt; Eva Amalie Nielsen; Vibeke Hjortdal; Morten Smerup
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-02
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  10     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  962-6     Citation Subset:  IM    
Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Skejby, Aarhus, Denmark.
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MeSH Terms
Animals, Newborn
Disease Models, Animal*
Feasibility Studies
Heart Catheterization
Hypertrophy, Right Ventricular / etiology*,  pathology,  physiopathology
Magnetic Resonance Imaging
Myocardial Contraction
Pulmonary Valve / surgery*
Pulmonary Valve Insufficiency / complications*,  pathology,  physiopathology
Reproducibility of Results
Stroke Volume
Suture Techniques*
Ventricular Dysfunction, Right / etiology*,  pathology,  physiopathology
Ventricular Function, Left
Ventricular Function, Right

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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