Document Detail

A novel polymorphism in secretory phospholipase A2-IID is associated with body weight loss in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  16002569     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Chronic and systemic inflammation, a potential cause of body weight loss in patients with chronic obstructive pulmonary disease (COPD), may be associated with the proinflammatory properties of secretory phospholipases A2 (sPLA2s), especially the group II subfamily sPLA2s.
OBJECTIVES: We tested our hypothesis that the individual susceptibility to body weight loss in patients with COPD is attributed to the genetic variances of this sPLA2 gene region.
METHODS: A total of 12 single nucleotide polymorphisms (SNPs) encompassing the sPLA2 gene region were determined in 276 male patients with COPD.
MEASUREMENTS AND MAIN RESULTS: We first analyzed our patients whose body mass index (BMI) was at the bottom 100 (BMI, 17.13 +/- 1.29 kg/m2) and at the top 100 (23.83 +/- 1.98) in relation to SNPs. Both the Fisher's exact test (odds ratio, 2.36; 95% confidence interval, 1.34-4.18; p = 0.004) and logistic regression analysis (odds ratio, 2.10; 95% confidence interval, 1.13-3.90; p = 0.019) showed statistical significance between one SNP (National Center for Biotechnology Information SNP reference: rs584367) and the reduction of BMI in the recessive model in patients with COPD. Using all the patients, a significant difference between the values of BMI (log transformed) of the mutant group (CT + TT) and that of the nonmutant group (CC) of this SNP (mean [SE], 1.293 [0.005] vs. 1.317 [0.006]; p = 0.003) was found after adjustment for age, smoking habit, and pulmonary function (analysis of covariance). Importantly, this SNP caused a change in amino acids in sPLA2-IID protein (Gly80Ser).
CONCLUSIONS: These results suggest that sPLA2-IID may be one of the susceptibility genes that contribute to body weight loss in patients with COPD.
Noriaki Takabatake; Makoto Sata; Sumito Inoue; Yoko Shibata; Shuichi Abe; Toshihiro Wada; Jun-Ichi Machiya; Guijin Ji; Tadashi Matsuura; Yasuchika Takeishi; Masaaki Muramatsu; Isao Kubota
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-07-07
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  172     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-26     Completed Date:  2006-01-19     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1097-104     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Body Mass Index
Genetic Predisposition to Disease
Group II Phospholipases A2
Middle Aged
Phospholipases A / genetics*
Phospholipases A2
Polymorphism, Single Nucleotide / genetics*
Pulmonary Disease, Chronic Obstructive / complications,  genetics*
Regression Analysis
Respiratory Function Tests
Weight Loss / genetics*
Reg. No./Substance:
EC 3.1.1.-/Phospholipases A; EC II Phospholipases A2; EC protein, human; EC A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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