Document Detail


A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma.
MedLine Citation:
PMID:  18204779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cysteinyl-leukotrienes are important pro-inflammatory mediators in bronchial asthma (BA) and are derived from arachidonic acid by the action of 5-lipoxygenase. We identified a novel polymorphism, c.760 G>A (E254K), in exon 6 of the 5-lipoxygenase gene (5-LO). This substitution was detected in 11 out of 180 patients with BA, but not in any of the 150 non-allergic subjects. The frequency of c.760 G>A showed a significant difference between BA and non-allergic subjects (P=0.0007). The c.760 G>A polymorphism existed at the surface edge of the C-terminal catalytic domain, and the E-to-K substitution changed the charge of the side chain from negative to positive. Thus, our results suggest that E254K in the 5-LO might be associated with BA.
Authors:
Chunying Bai; Eiko Matsui; Hidenori Ohnishi; Kaori Kimata; Kimiko Kasahara; Hideo Kaneko; Zenichiro Kato; Toshiyuki Fukao; Naomi Kondo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of molecular medicine     Volume:  21     ISSN:  1107-3756     ISO Abbreviation:  Int. J. Mol. Med.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-21     Completed Date:  2008-03-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9810955     Medline TA:  Int J Mol Med     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501-1193, Japan.
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MeSH Terms
Descriptor/Qualifier:
Arachidonate 5-Lipoxygenase / chemistry,  genetics*,  metabolism
Asthma / enzymology*,  genetics*
Base Sequence
Child
DNA Mutational Analysis
Female
Gene Expression Regulation, Enzymologic / drug effects
Gene Frequency
Genetic Predisposition to Disease*
Glutamic Acid / genetics*
Humans
Ionomycin
Leukotriene B4 / urine
Leukotriene E4 / urine
Lysine / genetics*
Male
Models, Molecular
Molecular Sequence Data
Neutrophils / drug effects,  metabolism
Polymorphism, Genetic*
RNA, Messenger / genetics,  metabolism
Structural Homology, Protein
Chemical
Reg. No./Substance:
0/RNA, Messenger; 56-86-0/Glutamic Acid; 56-87-1/Lysine; 56092-81-0/Ionomycin; 71160-24-2/Leukotriene B4; 75715-89-8/Leukotriene E4; EC 1.13.11.34/Arachidonate 5-Lipoxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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