Document Detail

A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma.
MedLine Citation:
PMID:  18204779     Owner:  NLM     Status:  MEDLINE    
Cysteinyl-leukotrienes are important pro-inflammatory mediators in bronchial asthma (BA) and are derived from arachidonic acid by the action of 5-lipoxygenase. We identified a novel polymorphism, c.760 G>A (E254K), in exon 6 of the 5-lipoxygenase gene (5-LO). This substitution was detected in 11 out of 180 patients with BA, but not in any of the 150 non-allergic subjects. The frequency of c.760 G>A showed a significant difference between BA and non-allergic subjects (P=0.0007). The c.760 G>A polymorphism existed at the surface edge of the C-terminal catalytic domain, and the E-to-K substitution changed the charge of the side chain from negative to positive. Thus, our results suggest that E254K in the 5-LO might be associated with BA.
Chunying Bai; Eiko Matsui; Hidenori Ohnishi; Kaori Kimata; Kimiko Kasahara; Hideo Kaneko; Zenichiro Kato; Toshiyuki Fukao; Naomi Kondo
Related Documents :
11577559 - Dna immunomodulation of asthma.
16830339 - Comparison of snp tagging methods using empirical data: association study of 713 snps o...
17634449 - Genomewide association analysis of coronary artery disease.
23485799 - Three-dimensional positioning of b chromosomes in fibroblast nuclei of the red fox and ...
23408799 - Y chromosome analysis of dingoes and southeast asian village dogs suggests a neolithic ...
19329499 - A genetic variant on chromosome 9p21 and incident heart failure in the aric study.
23319689 - Complex, not monosomal, karyotype is the cytogenetic marker of poorest prognosis in pat...
7977379 - Refining the region of branchio-oto-renal syndrome and defining the flanking markers on...
1503549 - Male sexual signaling is defective in mutants of the apterous gene of drosophila melano...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of molecular medicine     Volume:  21     ISSN:  1107-3756     ISO Abbreviation:  Int. J. Mol. Med.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-21     Completed Date:  2008-03-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9810955     Medline TA:  Int J Mol Med     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM    
Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501-1193, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arachidonate 5-Lipoxygenase / chemistry,  genetics*,  metabolism
Asthma / enzymology*,  genetics*
Base Sequence
DNA Mutational Analysis
Gene Expression Regulation, Enzymologic / drug effects
Gene Frequency
Genetic Predisposition to Disease*
Glutamic Acid / genetics*
Leukotriene B4 / urine
Leukotriene E4 / urine
Lysine / genetics*
Models, Molecular
Molecular Sequence Data
Neutrophils / drug effects,  metabolism
Polymorphism, Genetic*
RNA, Messenger / genetics,  metabolism
Structural Homology, Protein
Reg. No./Substance:
0/RNA, Messenger; 56-86-0/Glutamic Acid; 56-87-1/Lysine; 56092-81-0/Ionomycin; 71160-24-2/Leukotriene B4; 75715-89-8/Leukotriene E4; EC 5-Lipoxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinics in diagnostic imaging (120). Right rhinogenic optic neuritis secondary to mucocoele of the O...
Next Document:  CDC25A inhibition suppresses the growth and invasion of human hepatocellular carcinoma cells.