| A novel polymer-paclitaxel conjugate based on amphiphilic triblock copolymer. | |
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MedLine Citation:
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PMID: 17188776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel amphiphilic polymer-paclitaxel conjugate P(LGG-paclitaxel)-PEG-P(LGG-paclitaxel) has been prepared. It was derived from its parent polymer P(LGG)-PEG-P(LGG), poly{(lactic acid)-co-[(glycolic acid)-alt-(l-glutamic acid)]}-block-poly(ethylene glycol)-block-poly{(lactic acid)-co-[(glycolic acid)-alt-(l-glutamic acid)]}, which was prepared by ring-opening copolymerization of l-lactide (LLA) with (3s)-benzoxylcarbonylethyl-morpholine-2,5-dione (BEMD) in the presence of dihydroxyl PEG with molecular weight of 4600 as a macroinitiator using stannous octoate (Sn(Oct)(2)) as catalyst, and by subsequent catalytic hydrogenation. It could self-assemble into micelles in an aqueous system with P(LGG-paclitaxel) block in the core and PEG in the shell. ESEM and DLS analysis of the micelles revealed a homogeneous spherical morphology and a unimodal size distribution. In vitro release of paclitaxel from the conjugate micelles showed that its release rate depended on pH value and was higher at lower pH than in neutral condition. In vitro antitumor activity of the paclitaxel conjugate against rat brain glioma C6 cells was evaluated by MTT method. The results showed that the paclitaxel can be released from the conjugate without losing cytotoxicity. |
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Authors:
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Zhigang Xie; Huili Guan; Xuesi Chen; Changhai Lu; Li Chen; Xiuli Hu; Quan Shi; Xiabin Jing |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-11-23 |
Journal Detail:
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Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 117 ISSN: 0168-3659 ISO Abbreviation: J Control Release Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-02 Completed Date: 2007-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
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Languages: eng Pagination: 210-6 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Phytogenic / administration & dosage, chemistry, pharmacology Biological Availability Cell Line, Tumor Cell Survival / drug effects Delayed-Action Preparations / chemical synthesis, chemistry Drug Delivery Systems / methods Hydrogen-Ion Concentration Magnetic Resonance Spectroscopy Micelles Microscopy, Electron, Scanning Molecular Weight Paclitaxel / administration & dosage, chemistry*, pharmacology Particle Size Polyesters / chemical synthesis, chemistry* Polyethylene Glycols / chemical synthesis, chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Delayed-Action Preparations; 0/Micelles; 0/Polyesters; 0/Polyethylene Glycols; 0/poly(lactic acid-co-((glycolic acid)-alt-(L-glutamic acid))glucose)-poly(ethylene glycol)-poly(lactic acid-co-((glycolic acid)-alt-(L-glutamic acid))glucose); 33069-62-4/Paclitaxel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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