| A novel phosphatidylcholine hydrolysing action of C-reactive protein. | |
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MedLine Citation:
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PMID: 7702604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have observed a novel time and dose dependent stimulatory effect of CRP on the hydrolysis of dipalmitoyl phosphatidylcholine (DPPC) into phosphorylcholine (P-choline) and diacylglycerol (DAG). This effect was shared by rat, rabbit, human and asialo-rat CRP but not by other serum proteins, i.e., albumin, ovalbumin and alpha 1-acid glycoprotein. DPPC was also hydrolysed by normal rat serum (contains CRP) but not when serum was depleted of CRP. There is a requirement of Ca2+ for this unsuspected effect which was observed over a wide range of pH and the effect was markedly increased in temperatures up to 48 degrees C. The hydrolysis of DPPC showed a 3-fold decrease in Km when the assays included rat CRP. Massive increase of CRP in response to inflammation and its involvement in host defense reactions have been well documented. Significance of the present study rests on the possibility that the mechanism of action of CRP in cellular metabolism might be related to the production of DAG and P-choline known to have roles respectively in signal transduction and growth factor stimulated DNA synthesis. |
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Authors:
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S Mookerjea; D Hunt |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 208 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-05-01 Completed Date: 1995-05-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1046-52 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Memorial University of Newfoundland, St. John's, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1,2-Dipalmitoylphosphatidylcholine
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metabolism* Animals Blood Proteins / metabolism* C-Reactive Protein / metabolism* Diglycerides / analysis Humans Hydrolysis Kinetics Liposomes Phosphorylcholine / analysis Rabbits Rats Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Diglycerides; 0/Liposomes; 107-73-3/Phosphorylcholine; 2644-64-6/1,2-Dipalmitoylphosphatidylcholine; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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