Document Detail

A novel perspective on natural therapeutic approaches in glaucoma therapy.
MedLine Citation:
PMID:  17604496     Owner:  NLM     Status:  MEDLINE    
Glaucoma is becoming recognised as a condition for which not only elevated intraocular pressure (IOP), but also non-pressure-dependent risk factors, are responsible. Better knowledge of the pathogenesis has opened up new therapeutic approaches that are often referred to as non-IOP-lowering treatment. These new avenues of treatment, some of which are still under investigation, include agents that can improve vascular regulation and blood flow to the eye and reduce oxidative stress. Vascular regulation can be improved systemically with magnesium. Dark chocolate and omega-3-fatty acids can also improve blood flow regulation. Oxidative stress at mitochondrial level can be reduced by gingko. Polyphenolic flavonoids (tea, coffee and red wine), anthocyanosides, ubiquinone and melatonin have antioxidant properties, and heat-shock proteins can be induced naturally by the use of sauna baths. Future intensive studies on the effect of these compounds may open up a new therapeutic era in glaucoma.
Maneli Mozaffarieh; Josef Flammer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on emerging drugs     Volume:  12     ISSN:  1744-7623     ISO Abbreviation:  Expert Opin Emerg Drugs     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-07-02     Completed Date:  2007-08-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101135662     Medline TA:  Expert Opin Emerg Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  IM    
University Eye Clinic Basel, Mittlere Strasse 91, PO Box, CH-4031 Basel, Switzerland.
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MeSH Terms
Antioxidants / administration & dosage
Complementary Therapies / methods,  trends*
Fatty Acids, Omega-3 / administration & dosage
Ginkgo biloba
Glaucoma / diagnosis,  diet therapy,  metabolism,  therapy*
Oxidative Stress / drug effects,  physiology
Reg. No./Substance:
0/Antioxidants; 0/Coffee; 0/Fatty Acids, Omega-3

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