| A novel peroxynitrite decomposer catalyst (FP-15) reduces myocardial infarct size in an in vivo peroxynitrite decomposer and acute ischemia-reperfusion in pigs. | |
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MedLine Citation:
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PMID: 12400769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Reactive oxygen and nitrogen species generated after reperfusion injury result in organ dysfunction. Peroxynitrite, a reactive nitrogen molecule produced from the reaction of superoxide anions and nitric oxide, is thought to be a causative agent in oxidative reperfusion injury. The aim of this study was to investigate the effects of a novel peroxynitrite decomposition catalyst (FP-15) in an acute myocardial ischemia/reperfusion model. METHODS: Pigs were subjected to 60 minutes of regional ischemia by reversibly ligating the left anterior descending coronary artery followed by 180 minutes of reperfusion. In the treatment group (n = 6), an FP-15 (1 mg/kg) bolus was infused through the jugular vein after 30 minutes of ischemia followed by a continuous infusion (1 mg x kg(-1) x h(-1)) during reperfusion. Vehicle was infused in the control group (n = 6). Coronary flow was recorded by an ultrasonic flow probe and infarct size determined by tetrazolium staining. Arterial and left ventricular pressures were monitored continuously and regional myocardial function determined by sonomicrometry. RESULTS: No significant differences were observed in either hemodynamics or ischemic area at risk. However, the infarct size was significantly reduced (35.3% +/- 3.5% versus 21.6% +/- 2.6% of the ischemic area, control versus FP-15-treated groups, respectively, p < 0.05). +dP/dt was transiently improved in the FP-15-treated groups while during most of the reperfusion period coronary flow, and was significantly lower in the FP-15-treated group as compared to the control group (p < 0.01). CONCLUSIONS: FP-15 administration reduces myocardial infarct size and reactive hyperemia. These data support the pathogenic role of endogenously produced peroxynitrite and that FP-15 is effective in preventing myocardial reperfusion injury. |
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Authors:
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Cesario Bianchi; Hidetaka Wakiyama; Renato Faro; Tanveer Khan; James D McCully; Sidney Levitsky; Csaba Szabó; Frank W Sellke |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 74 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-28 Completed Date: 2002-11-26 Revised Date: 2013-04-30 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1201-7 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / drug effects Disease Models, Animal Female Male Myocardial Infarction / pathology* Myocardial Reperfusion Injury / metabolism*, physiopathology, prevention & control Peroxynitrous Acid / metabolism* Swine |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL-46716/HL/NHLBI NIH HHS; R01 HL029077/HL/NHLBI NIH HHS; R43 HL-65863/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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14691-52-2/Peroxynitrous Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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