Document Detail

A novel pacing manoeuvre to diagnose atrial tachycardia.
MedLine Citation:
PMID:  18299309     Owner:  NLM     Status:  MEDLINE    
AIMS: Currently used diagnostic manoeuvres at the electrophysiology study do not always allow for consistent identification of atrial tachycardia (AT), either because of inapplicability of the technique or because of low predictive value and specificity. The aim of this study was to determine whether overdrive atrial pacing during paroxysmal supraventricular tachycardia (SVT) with the same cycle length from both the high right atrium and the coronary sinus can accurately identify or exclude AT by examining the difference between the V-A intervals of the first returning beat of tachycardia between the two pacing sites. METHODS AND RESULTS: Fifty-two patients were included; 24 patients with atrioventricular nodal re-entry tachycardia (AVNRT), 13 patients with atrioventricular re-entry tachycardia (AVRT), and 15 patients with AT. Comparing the 37 non-AT patients with the 15 AT patients, there was a highly significant difference between the mean V-A interval difference, (delta V-A) 2.1 +/- 1.8 ms (range 0-9 ms) vs. 79.1 +/- 42 (range 22-267 ms) (P < 0.001), respectively. None of the patients in the non-AT group had a delta V-A > 10 ms. In contrast, all 15 patients with AT had a delta V-A interval >10 ms. Thus, the diagnostic accuracy of the delta V-A interval cut-off of >10 ms was 100%, with a 95% confidence interval of 93.1-100% for AT. In 11 (73%) of the 15 AT patients, the standard ventricular overdrive pacing manoeuvre was not possible. In 14 of the 15 patients (93%) in the AT group, standard atrial overdrive pacing showed variable V-A intervals, correctly diagnosing AT. In all 52 patients, this measurement was repeated during pacing from the other location. In five patients from the AT group, the result of the second attempt was different from the result of the first attempt. CONCLUSION: We found that atrial differential pacing during paroxysmal SVT without termination of tachycardia and the finding of variable returning V-A interval was highly sensitive and specific for the diagnosis of AT. The manoeuvre can be easily performed in all patients with SVT and is highly reproducible. It is a useful adjunct to the currently available ventricular and atrial pacing manoeuvres.
Andrea Sarkozy; Sergio Richter; Gian-Battista Chierchia; Carlo De Asmundis; Christos Seferlis; Pedro Brugada; Leonard Kaufman; Ronald Buyl; Paul Dorian; Iqwal Mangat
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-02-25
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  10     ISSN:  1532-2092     ISO Abbreviation:  Europace     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-26     Completed Date:  2008-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-66     Citation Subset:  IM    
Heart Rhythm Management Center, Cardiovascular Center, UZ Brussel-Vrije Universiteit Brussel, Laarbeeklaan 101, Brussels 1090, Belgium.
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MeSH Terms
Cardiac Pacing, Artificial / methods*
Coronary Sinus / physiopathology
Diagnosis, Differential
Electrophysiologic Techniques, Cardiac
Heart Atria / physiopathology
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Tachycardia, Atrioventricular Nodal Reentry / diagnosis*,  physiopathology
Tachycardia, Paroxysmal / diagnosis*,  physiopathology
Tachycardia, Supraventricular / diagnosis*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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