| The novel oral imatinib microemulsions: physical properties, cytotoxicity activities and improved Caco-2 cell permeability. | |
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MedLine Citation:
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PMID: 22789009 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The objective of this study was to formulate imatinib (IM) loaded to water-in-oil (w/o) microemulsions as an alternative formulation for cancer therapy and to evaluate the cytotoxic effect of microemulsions Caco-2 and MCF-7. Moreover, permeability studies were also performed with Caco-2 cells. W/o microemulsion systems were developed by using pseudo-ternary phase diagram. According to cytotoxicity studies, all formulations did not exert a cytotoxic effect on Caco-2 cells. Furthermore, all formulations had a significant cytotoxic effect on MCF-7 cells and the cytotoxic effect of M3IM was significantly more than that of other microemulsions and IM solution (p < 0.05). The permeability studies of IM across Caco-2 cells showed that permeability value from apical to basolateral was higher than permeability value of other formulations. In conclusion, the microemulsion formulations as a drug carrier, especially M3IM formulation, may be used as an effective alternative breast cancer therapy for oral delivery of IM. |
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Authors:
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Evren Gundogdu; Hatice Yesim Karasulu; Cinel Koksal; Ercüment Karasulu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-12 |
Journal Detail:
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Title: Journal of microencapsulation Volume: - ISSN: 1464-5246 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500513 Medline TA: J Microencapsul Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, Ege University , Izmir 35100 , Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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