Document Detail


A novel open field activity detector to determine spatial and temporal movement of laboratory animals after injury and disease.
MedLine Citation:
PMID:  16735064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The wide range of tests for laboratory animal behavior after neurological injury or disease each have their benefits and detriments. The varied behavior an animal exhibits makes it difficult to decide which test to use. However, a fundamental instinct for the laboratory animal is to explore when placed in a new environment. A way to test exploratory behavior is in the open field. Here, we introduce a simple activity box without the use of video equipment to determine the exploratory movement of a rat after traumatic brain injury. The activity box is an open field and the rat explores its surroundings when placed inside. Four infrared beams were placed in both the X and Y-axis inside the box. Using a novel system to determine which beam the rat breaks, we describe where the rat is in space and time while in the activity box. Other models can show the number of beams broken, but here we elucidate the methods to additionally determine the amount of area explored, the total distance traveled by the rat and percent time exploring.
Authors:
Andrew O Koob; John Cirillo; Charles F Babbs
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Publication Detail:
Type:  Journal Article     Date:  2006-06-02
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  157     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-11     Completed Date:  2006-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  330-6     Citation Subset:  IM    
Affiliation:
Department of Pediatric Neurosurgery, Dartmouth Hitchcock Medical Center, Dartmouth College, Lebanon, NH 03756, USA. Andrew.O.Koob@Dartmouth.EDU
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Injuries / physiopathology*
Exploratory Behavior / physiology*
Motor Activity / physiology*
Rats
Spatial Behavior / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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