Document Detail

A novel open field activity detector to determine spatial and temporal movement of laboratory animals after injury and disease.
MedLine Citation:
PMID:  16735064     Owner:  NLM     Status:  MEDLINE    
The wide range of tests for laboratory animal behavior after neurological injury or disease each have their benefits and detriments. The varied behavior an animal exhibits makes it difficult to decide which test to use. However, a fundamental instinct for the laboratory animal is to explore when placed in a new environment. A way to test exploratory behavior is in the open field. Here, we introduce a simple activity box without the use of video equipment to determine the exploratory movement of a rat after traumatic brain injury. The activity box is an open field and the rat explores its surroundings when placed inside. Four infrared beams were placed in both the X and Y-axis inside the box. Using a novel system to determine which beam the rat breaks, we describe where the rat is in space and time while in the activity box. Other models can show the number of beams broken, but here we elucidate the methods to additionally determine the amount of area explored, the total distance traveled by the rat and percent time exploring.
Andrew O Koob; John Cirillo; Charles F Babbs
Related Documents :
6311574 - Effect of cholecystokinin on self-stimulation behavior in rats.
6670974 - Inhibitory avoidance deficit following short-term adrenalectomy in the rat: the role of...
8118684 - Lateralized changes in prefrontal cortical dopamine activity induced by controllable an...
8570034 - Influence of damage to the suprachiasmatic nuclei of the hypothalamus of rats on the dy...
6712354 - Effect of taurocholate pretreatment on the biliary excretion of exogenous organic anion...
9524314 - Pharmacokinetic examination of p-aminobenzoic acid passage through the placenta and the...
Publication Detail:
Type:  Journal Article     Date:  2006-06-02
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  157     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-11     Completed Date:  2006-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  330-6     Citation Subset:  IM    
Department of Pediatric Neurosurgery, Dartmouth Hitchcock Medical Center, Dartmouth College, Lebanon, NH 03756, USA. Andrew.O.Koob@Dartmouth.EDU
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain Injuries / physiopathology*
Exploratory Behavior / physiology*
Motor Activity / physiology*
Spatial Behavior / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to ...
Next Document:  Quantification of human neural stem cell engraftments in rat brains using ERV-3 real-time PCR.