| A novel needle-free powder lidocaine delivery system for rapid local analgesia. | |
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MedLine Citation:
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PMID: 18280850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the analgesic effect and tolerability of a novel needle-free powder lidocaine delivery system in children undergoing venipuncture. STUDY DESIGN: In this double-blind, placebo-controlled, single-center trial, 306 children age 3 to 18 years were randomized to receive a needle-free powder lidocaine delivery system or matching sham placebo at the back of the hand 2 to 3 minutes before venipuncture. Venipuncture pain was self-reported using the Wong-Baker FACES scale (in 3- to 12-year-olds) and a 100-mm visual analog scale (in 8- to 18-year-olds). Safety was assessed by adverse events, investigator skin site assessments, and children's self-report of the administration comfort of study treatments. Effect sizes were compared by 2-sample t test and Glass's Delta approach. RESULTS: Subjects receiving the needle-free powder lidocaine delivery system exhibited mean pain reductions (effect size) of 33% to 46% relative to sham placebo. Pain reductions were statistically significant for all ages combined and also for the youngest and oldest age strata. Self-reported administration comfort levels were similar in the active system and sham placebo groups. Incidences of adverse events and dermal reactions were low; the most common dermal reaction was mild erythema. CONCLUSIONS: The needle-free powder lidocaine delivery system was well tolerated and provided effective local analgesia when administered 2 to 3 minutes before venipuncture. |
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Authors:
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William T Zempsky; Bertha Robbins; Patricia T Richards; Michael S Leong; Neil L Schechter |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-10-22 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 152 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-18 Completed Date: 2008-03-18 Revised Date: 2008-09-30 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 405-11 Citation Subset: AIM; IM |
Affiliation:
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Pain Relief Program, Connecticut Children's Medical Center, Hartford, CT, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Factors Anesthesia, Local / methods* Anesthetics, Local / administration & dosage* Child Child, Preschool Confidence Intervals Double-Blind Method Drug Delivery Systems Female Follow-Up Studies Humans Lidocaine / administration & dosage* Male Pain / drug therapy* Pain Measurement Prospective Studies Reference Values Risk Assessment Sex Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 137-58-6/Lidocaine |
| Comments/Corrections | |
Comment In:
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Evid Based Nurs. 2008 Oct;11(4):106
[PMID:
18815318
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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