Document Detail


A novel monoclonal antibody effective against lethal challenge with swine-lineage and 2009 pandemic H1N1 influenza viruses in mice.
MedLine Citation:
PMID:  21774955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The HA protein of the 2009 pandemic H1N1 viruses (H1N1pdm) is antigenically closely related to the HA of classical North American swine H1N1 influenza viruses (cH1N1). Since 1998, through mutation and reassortment of HA genes from human H3N2 and H1N1 influenza viruses, swine influenza strains are undergoing substantial antigenic drift and shift. In this report we describe the development of a novel monoclonal antibody (S-OIV-3B2) that shows high hemagglutination inhibition (HI) and neutralization titers not only against H1N1pdm, but also against representatives of the α, β, and γ clusters of swine-lineage H1 influenza viruses. Mice that received a single intranasal dose of S-OIV-3B2 were protected against lethal challenge with either H1N1pdm or cH1N1 virus. These studies highlight the potential use of S-OIV-3B2 as effective intranasal prophylactic or therapeutic antiviral treatment for swine-lineage H1 influenza virus infections.
Authors:
Hongxia Shao; Jianqiang Ye; Amy L Vincent; Nicole Edworthy; Andrea Ferrero; Aijian Qin; Daniel R Perez
Related Documents :
21858235 - Correction: in-depth analysis of the antibody response of individuals exposed to primar...
21987765 - Conserved proline-rich region of ebola virus matrix protein vp40 is essential for plasm...
21046175 - Proposal for a revised taxonomy of the family filoviridae: classification, names of tax...
21936715 - The hematopoietic cell-specific rho gtpase inhibitor arhgdib/d4gdi limits hiv-1 replica...
20936505 - Comparative sequence analysis of b5r gene of zoonotic buffalo pox virus isolates with o...
21475275 - Identification of herpesvirus types 1 to 8 and human papillomavirus in acute apical abs...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-07-19
Journal Detail:
Title:  Virology     Volume:  417     ISSN:  1096-0341     ISO Abbreviation:  Virology     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2011-10-18     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Key Laboratory of Jiangsu Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / administration & dosage*,  immunology
Antibodies, Neutralizing / administration & dosage,  immunology
Antibodies, Viral / administration & dosage*,  immunology
Disease Models, Animal
Female
Hemagglutination Inhibition Tests
Influenza A Virus, H1N1 Subtype / immunology*
Mice
Mice, Inbred BALB C
Neutralization Tests
Orthomyxoviridae Infections / immunology,  mortality,  prevention & control*
Rodent Diseases / mortality,  prevention & control,  virology
Survival Analysis
Grant Support
ID/Acronym/Agency:
HHSN266186700010C//PHS HHS; R21 AI071014-02/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Neutralizing; 0/Antibodies, Viral
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The oral administration of thermophile-fermented compost extract and its influence on stillbirths an...
Next Document:  Treatment of nanofiltration and reverse osmosis concentrates: Comparison of precipitative softening,...