Document Detail

A novel monoclonal antibody effective against lethal challenge with swine-lineage and 2009 pandemic H1N1 influenza viruses in mice.
MedLine Citation:
PMID:  21774955     Owner:  NLM     Status:  MEDLINE    
The HA protein of the 2009 pandemic H1N1 viruses (H1N1pdm) is antigenically closely related to the HA of classical North American swine H1N1 influenza viruses (cH1N1). Since 1998, through mutation and reassortment of HA genes from human H3N2 and H1N1 influenza viruses, swine influenza strains are undergoing substantial antigenic drift and shift. In this report we describe the development of a novel monoclonal antibody (S-OIV-3B2) that shows high hemagglutination inhibition (HI) and neutralization titers not only against H1N1pdm, but also against representatives of the α, β, and γ clusters of swine-lineage H1 influenza viruses. Mice that received a single intranasal dose of S-OIV-3B2 were protected against lethal challenge with either H1N1pdm or cH1N1 virus. These studies highlight the potential use of S-OIV-3B2 as effective intranasal prophylactic or therapeutic antiviral treatment for swine-lineage H1 influenza virus infections.
Hongxia Shao; Jianqiang Ye; Amy L Vincent; Nicole Edworthy; Andrea Ferrero; Aijian Qin; Daniel R Perez
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-07-19
Journal Detail:
Title:  Virology     Volume:  417     ISSN:  1096-0341     ISO Abbreviation:  Virology     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2011-10-18     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Antibodies, Monoclonal / administration & dosage*,  immunology
Antibodies, Neutralizing / administration & dosage,  immunology
Antibodies, Viral / administration & dosage*,  immunology
Disease Models, Animal
Hemagglutination Inhibition Tests
Influenza A Virus, H1N1 Subtype / immunology*
Mice, Inbred BALB C
Neutralization Tests
Orthomyxoviridae Infections / immunology,  mortality,  prevention & control*
Rodent Diseases / mortality,  prevention & control,  virology
Survival Analysis
Grant Support
HHSN266186700010C//PHS HHS; R21 AI071014/AI/NIAID NIH HHS; R21 AI071014-02/AI/NIAID NIH HHS
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Neutralizing; 0/Antibodies, Viral

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