| A novel mono-carbonyl analogue of curcumin induces apoptosis in ovarian carcinoma cells via endoplasmic reticulum stress and reactive oxygen species production. | |
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MedLine Citation:
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PMID: 22159410 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of the present study was to investigate the apoptosis of human ovarian cancer cell lines, A2780 and CP70, induced by a novel curcumin analogue, B19. The proliferation of cells was detected with methyl thiazolyl tetrazolium (MTT) assay and apoptosis was examined by flow cytometry. Reactive oxygen species (ROS) were assessed by the fluorescent indicator DCF-DA. The protein expression of the endoplasmic reticulum (ER) stress pathways, GRP78, XBP-1, ATF-4 and CHOP, was examined with Western blotting. A growth inhibitory effect was observed after treatment with B19 in a dose-dependent manner and with more potential than curcumin. At 20 µM, B19 induced significant apoptosis in CP70 cells. Furthermore, B19 induced the ER stress response, while curcumin had no effect on ER stress. These results suggest that B19 has more effective antitumor properties than curcumin, and is associated with the activation of ER stress and ROS in ovarian cancer cells. |
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Authors:
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Xie Zhang; Han-Qing Zhang; Guang-Hui Zhu; Yu-Huang Wang; Xi-Chong Yu; Xin-Bo Zhu; Guang Liang; Jian Xiao; Xiao-Kun Li |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-09 |
Journal Detail:
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Title: Molecular medicine reports Volume: - ISSN: 1791-3004 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101475259 Medline TA: Mol Med Report Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Key Laboratory of Biotechnology Pharmaceutical Engineering, School of Pharmaceutical Science, Wenzhou Medical College, Wenzhou, Zhejiang 325035, P.R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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