Document Detail

A novel mitotropic oligolysine nanocarrier: Targeted delivery of covalently bound d-luciferin to cell mitochondria.
MedLine Citation:
PMID:  21856448     Owner:  NLM     Status:  Publisher    
New and emerging therapeutic approaches focus on the targeted delivery of therapeutic agents to cell mitochondria with high specificity. Herein we present a novel mitotropic nanocarrier based on an oligolysine scaffold by addition of two triphenylphosphonium cations per oligomer. Although the parent oligolysine failed to enter healthy cells, the triphenylphosphonium modified carrier, with or without d-Luciferin, attached as cargo molecule, demonstrated striking mitochondrial specificity. Furthermore, the oligolysine bound d-Luciferin exhibited chemiluminescence, of lower intensity than free d-Luciferin, yet of remarkably longer steady-state temporal profile.
Theodossis A Theodossiou; Zili Sideratou; Dimitris Tsiourvas; Constantinos M Paleos
Related Documents :
6443748 - Testicular peptides and their endocrine and paracrine functions.
2551638 - Regulation of leydig cell function in primary culture by inhibin and activin.
6637858 - Colchicine-induced changes in the cytoskeleton of the golden-mantled ground squirrel (s...
3080308 - Two-dimensional gel analysis of sertoli cell protein phosphorylation: effect of short t...
15110478 - Oligo-3-hydroxybutyrates as potential carriers for drug delivery.
20924998 - Brain lesions in tuberous sclerosis complex. review.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-11
Journal Detail:
Title:  Mitochondrion     Volume:  -     ISSN:  1872-8278     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100968751     Medline TA:  Mitochondrion     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Berberine inhibits the production of thymic stromal lymphopoietin by the blockade of caspase-1/NF-?B...
Next Document:  Are mitochondrial haplogroups associated with elite athletic status? A study on a Spanish cohort.