Document Detail


A novel microwave synthesis of quinoline-3-carboxylic acid derivatives for treatment against human African trypanosomiasis.
MedLine Citation:
PMID:  23054534     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A series of quinoline-3-carboxylic acid derivatives has been synthesized with easy reaction conditions (in aqueous micellar microreactors and using microwave irradiation) and tested for its biological activity against human African trypanosomiasis (HAT). From this series, several derivatives of quinoline-3-carboxylic acid such as 23 and 24 exhibited potent activity against Trypanosoma brucei in vitro and had low cytotoxicity. The combination of electron withdrawing and donating groups in the structure seems to be the crucial factor to inhibit T. brucei.
Authors:
Bhupesh S Samant; Nyaradzai Nyangari
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-10
Journal Detail:
Title:  Molecular diversity     Volume:  -     ISSN:  1573-501X     ISO Abbreviation:  Mol. Divers.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516534     Medline TA:  Mol Divers     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Natural Product and Medicinal Chemistry (NPMC) Research Group, Division of Pharmaceutical chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown, 6140, South Africa, b.samant@ru.ac.za.
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