| A novel, microscope based, non-invasive laser Doppler flowmeter for choroidal blood flow assessment. | |
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MedLine Citation:
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PMID: 21443871 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impaired ocular blood flow is involved in the pathogenesis of numerous ocular diseases like glaucoma or AMD. The purpose of the present study was to introduce and validate a novel, microscope based, non-invasive Laser Doppler Flowmeter (NI-LDF) for measurement of blood flow in the choroid. The custom made NI-LDF was compared with a commercial fiber optic based laser Doppler flowmeter (Perimed PF4000). Linearity and stability of the NI-LDF were assessed in a silastic tubing model (i.d. 0.3 mm) at different flow rates (range 0.4-3 ml/h). In a rabbit model continuous choroidal blood flow measurements were performed with both instruments simultaneously. During blood flow measurements ocular perfusion pressure was changed by manipulations of intraocular pressure via intravitreal saline infusions. The NI-LDF measurement correlated linearly to intraluminal flow rates in the perfused tubing model (r = 0.99, p < 0.05) and remained stable during a 1 h measurement at a constant flow rate. Rabbit choroidal blood flow measured by the PF4000 and the NI-LDF linearly correlated with each other over the entire measurement range (r = 0.99, y = x∗1.01-12.35 P.U., p < 0.001). In conclusion, the NI-LDF provides valid, semi quantitative measurements of capillary blood flow in comparison to an established LDF instrument and is suitable for measurements at the posterior pole of the eye. |
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Authors:
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C Strohmaier; R M Werkmeister; B Bogner; C Runge; F Schroedl; H Brandtner; W Radner; L Schmetterer; J W Kiel; G Grabner; H A Reitsamer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2011-04-01 |
Journal Detail:
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Title: Experimental eye research Volume: 92 ISSN: 1096-0007 ISO Abbreviation: Exp. Eye Res. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-30 Completed Date: 2011-08-09 Revised Date: 2012-02-10 |
Medline Journal Info:
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Nlm Unique ID: 0370707 Medline TA: Exp Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 545-51 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Ophthalmology and Optometry, Paracelsus Medical University, Müllner Haupstrasse 48, Salzburg 5020, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / physiology Choroid / blood supply* Female Intraocular Pressure / physiology Laser-Doppler Flowmetry / instrumentation* Male Microscopy / instrumentation* Rabbits Regional Blood Flow / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY009702-17/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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