Document Detail


A novel methodology for AV and VV delay optimization in CRT: results from a randomized pilot clinical trial.
MedLine Citation:
PMID:  23504186     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of this work was to determine whether the use of a newly developed methodology (Alg1) for AV and VV optimization improves cardiac resynchronization therapy (CRT) clinical and echocardiographic (ECHO) outcomes. In this single-center pilot clinical trial, 80 consecutive patients (79 % male; 70.1 ± 11.2 years) receiving CRT were randomly assigned to AV and VV optimization using Alg1 (group A) or standard commercial procedures (group B). Clinical status and ECHOs were analyzed at baseline (_0) , 3 (fu1), and 6 months (fu2) of follow-up evaluating left ventricular end systolic (LVESV) and end diastolic (LVEDV) volumes, ejection fraction (EF), Minnesota test, and 6-min walk test (6MWT). Alg1 is based on a cardiovascular model fed with patient data. Baseline characteristics did not differ significantly between groups. Group A had a better clinical outcome and reverse remodeling. Remodeling was calculated as the difference (Δ) between fu1 and _0 and between fu2 and fu1, respectively: [LVESV (ml): ΔA_fu1 = -55.3, ΔB_fu1 = -13.5, p_fu1 = 0.002; ΔA_fu2 = -22.8, ΔB_fu2 = 3.0, p_fu2 = 0.04], [LVEDV (ml): ΔA_fu1 = -61.9, ΔB_fu1 = -16.1, p_fu1 = 0.01; ΔA_fu2 = -30.4, ΔB_fu2 = 11.3, p_fu2 = 0.02]; Minnesota test: total (p_fu1 = 0.01; p_fu2 = 0.04), physical (p_fu1 = 0.01; p_fu2 = 0.03) and emotional scores (p_fu1 = 0.04; p_fu2 = 0.03) and in 6MWT (m) (p_fu2 = 0.008). No statistically significant difference was observed in QRS width. Compared with current standard of care, CRT optimization using Alg1 is associated with better outcomes, showing the power of a tailored CRT.
Authors:
Arianna Di Molfetta; Giovanni B Forleo; Luca Santini; Libera Fresiello; Lida P Papavasileiou; Giulia Magliano; Domenico Sergi; Ambrogio Capria; Francesco Romeo; Gianfranco Ferrari
Related Documents :
11357896 - The effects of intravenous doxycycline therapy for rheumatoid arthritis: a randomized, ...
20383886 - Anti-tnf-alpha therapy with infliximab in spondyloarthritides.
24693416 - The effects of ranitidine and hydrocortisone on the complications of femoral artery obs...
24927186 - Evaluation of the novasure endometrial ablation procedure in women with uterine cavity ...
18669146 - Early performance of voiding cystourethrogram after urinary tract infection in children.
2683326 - Cefixime versus trimethoprim/sulfamethoxazole in treatment of patients with acute, unco...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-16
Journal Detail:
Title:  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs     Volume:  -     ISSN:  1619-0904     ISO Abbreviation:  J Artif Organs     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815648     Medline TA:  J Artif Organs     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Cardiovascular Engineering Group, Institute of Clinical Physiology, Italian National Research Council, via San Martino della Battaglia, 44, 00185, Rome, Italy, arianna.dimolfetta@ifc.cnr.it.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Central giant cell lesion of the jaws: study of CCND1 gene amplification and p16(INK4a) protein leve...
Next Document:  Reflection-mode TERS on Insulin Amyloid Fibrils with Top-Visual AFM Probes.