Document Detail

A novel method for quantifying in-vivo regional left ventricular myocardial contractility in the border zone of a myocardial infarction.
MedLine Citation:
PMID:  22010752     Owner:  NLM     Status:  MEDLINE    
Homogeneous contractility is usually assigned to the remote region, border zone (BZ), and the infarct in existing infarcted left ventricle (LV) mathematical models. Within the LV, the contractile function is therefore discontinuous. Here, we hypothesize that the BZ may in fact define a smooth linear transition in contractility between the remote region and the infarct. To test this hypothesis, we developed a mathematical model of a sheep LV having an anteroapical infarct with linearly-varying BZ contractility. Using an existing optimization method (Sun et al., 2009, "A Computationally Efficient Formal Optimization of Regional Myocardial Contractility in a Sheep With Left Ventricular Aneurysm," J. Biomech. Eng., 131(11), pp. 111001), we use that model to extract active material parameter T(max) and BZ width d(n) that "best" predict in-vivo systolic strain fields measured from tagged magnetic resonance images (MRI). We confirm our hypothesis by showing that our model, compared to one that has homogeneous contractility assigned in each region, reduces the mean square errors between the predicted and the measured strain fields. Because the peak fiber stress differs significantly (~15%) between these two models, our result suggests that future mathematical LV models, particularly those used to analyze myocardial infarction treatment, should account for a smooth linear transition in contractility within the BZ.
Lik Chuan Lee; Jonathan F Wenk; Doron Klepach; Zhihong Zhang; David Saloner; Arthur W Wallace; Liang Ge; Mark B Ratcliffe; Julius M Guccione
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  133     ISSN:  1528-8951     ISO Abbreviation:  J Biomech Eng     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-20     Completed Date:  2012-02-15     Revised Date:  2013-07-17    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  094506     Citation Subset:  IM    
Departments of Surgery and Bioengineering, University of California, San Francisco, CA 94143, USA.
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MeSH Terms
Blood Pressure
Finite Element Analysis*
Heart Ventricles / physiopathology*
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Myocardial Contraction*
Myocardial Infarction / physiopathology*
Stress, Mechanical
Grant Support
R01 HL063348/HL/NHLBI NIH HHS; R01 HL063348-13/HL/NHLBI NIH HHS; R01 HL077921/HL/NHLBI NIH HHS; R01 HL077921-06/HL/NHLBI NIH HHS; R01 HL084431-04/HL/NHLBI NIH HHS; R01 HL086400/HL/NHLBI NIH HHS; R01 HL086400-02/HL/NHLBI NIH HHS

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