Document Detail

A novel method for low load friction testing on living cells.
MedLine Citation:
PMID:  18071637     Owner:  NLM     Status:  MEDLINE    
A low load tribology technique for studying the effects of friction on living cells was developed. Results show a direct relationship between the coefficient of friction (COF) and the extent of cell damage. The COF, mu, for a glass pin on an intact layer of human corneal epithelial cells is determined to be on the order of mu = 0.05 +/- 0.02 (n = 16). The correlations between applied normal load and extent of cell damage, as well as between number of reciprocation cycles and cell damage, are reported. It is also found that cell damage can occur when a loading force as low as 0.5 mN is applied, although the cells appear to be intact.
Jessica A Cobb; Alison C Dunn; Jiwoon Kwon; Malisa Sarntinoranont; W Gregory Sawyer; Roger Tran-Son-Tay
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Publication Detail:
Type:  Journal Article     Date:  2007-12-11
Journal Detail:
Title:  Biotechnology letters     Volume:  30     ISSN:  1573-6776     ISO Abbreviation:  Biotechnol. Lett.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-08-20     Revised Date:  2008-10-07    
Medline Journal Info:
Nlm Unique ID:  8008051     Medline TA:  Biotechnol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  801-6     Citation Subset:  IM    
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, P.O. Box 116131, Gainesville, FL, USA.
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MeSH Terms
Cell Line
Cell Survival
Epithelial Cells / physiology*
Epithelium, Corneal / physiology*
Microscopy, Interference
Stress, Mechanical

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