Document Detail

A novel method for estimating the focal size of two confocal high-intensity focused ultrasound transducers.
MedLine Citation:
PMID:  16018477     Owner:  NLM     Status:  MEDLINE    
Estimating the focal size and position of a high-intensity focused ultrasound (HIFU) transducer remains a challenge since traditional methods, such as hydrophone scanning or schlieren imaging, cannot tolerate high pressures, are directional, or provide low resolution. The difficulties increase when dealing with the complex beam pattern of a multielement HIFU transducer array, e.g., two transducers facing each other. In the present study we show a novel approach to the visualization of the HIFU focus by using shockwave-generated bubbles and a diagnostic B-mode scanner. Bubbles were generated and pushed by shock waves toward the HIFU beam, and were trapped in its pressure valleys. These trapped bubbles moved along the pressure valleys and thereby delineated the shape and size of the HIFU beam. The main and sidelobes of 1.1- and 3.5 MHz HIFU beams were clearly visible, and could be measured with a millimeter resolution. The combined foci could also be visualized by observing the generation of sustained inertial cavitation and enhanced scattering. The results of this study further demonstrate the possibility of reducing the inertial cavitation threshold by the local introduction of shock wave-generated bubbles, which might be useful when bubble generation and cavitation-related bioeffects are intended within a small region in vivo.
Wen-Shiang Chen; Ping-Mo Ma; Hao-Li Liu; Chih-Kuang Yeh; Min-Shin Chen; Chein-Wei Chang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  117     ISSN:  0001-4966     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-15     Completed Date:  2005-12-14     Revised Date:  2006-12-27    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3740-9     Citation Subset:  IM    
Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei 100, Taiwan.
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MeSH Terms
Equipment Design
Radio Waves
Ultrasonography / instrumentation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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