| A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes. | |
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MedLine Citation:
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PMID: 16854388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Beta-amyloid (Abeta) deposition and senile plaque-associated astrocytes are common neuropathological features of Alzheimer's disease (AD). Although the molecular mechanisms by which Abeta contributes to the progression of neuropathologic changes have not been entirely established, there is little doubt that the association of Abeta with astrocytes, the predominant cell type in brain, significantly influences exacerbation of the disease. In an effort to identify astrocyte-derived molecules that may be intimately associated with progression of AD, we identified a novel Abeta-induced rat gene, designated Mib, whose human counterpart covers KIAA0233. Mib-transfected C6 cells express Mib protein in the endoplasmic reticulum and endplasmic reticulum-Golgi-intermediate compartment. To evaluate roles of Mib in AD, we investigated its expression in the AD brain. In non-AD brains, Mib mRNA has been detected in neurons but not in quiescent astrocytes. On the contrary, in AD brains, Mib mRNA is expressed in activated astrocytes associated with senile plaques, but not expressed in neurons around lesions. From these observations, Mib appears to be a novel Abeta-responsive gene that may play a role in astrocyte inflammatory activation around senile plaques in the AD brain. |
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Authors:
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Kazuki Satoh; Mitsumi Hata; Seiji Takahara; Hidetoshi Tsuzaki; Hiroshi Yokota; Hiroyasu Akatsu; Takayuki Yamamoto; Kenji Kosaka; Tatsuo Yamada |
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Publication Detail:
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Type: Journal Article Date: 2006-07-18 |
Journal Detail:
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Title: Brain research Volume: 1108 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-28 Completed Date: 2006-12-06 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 19-27 Citation Subset: IM |
Affiliation:
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The Fifth Frontier Project, Daiichi Pharmaceutical Co., Ltd., Tokyo 134-8640, Japan. satohj7i@daiichipharm.co.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
/
genetics,
metabolism*,
physiopathology Animals Astrocytes / metabolism* Base Sequence Cell Line, Tumor Cells, Cultured Encephalitis / genetics, metabolism*, physiopathology Endoplasmic Reticulum / metabolism, ultrastructure Gene Expression Regulation / genetics Gliosis / genetics, metabolism*, physiopathology Golgi Apparatus / metabolism, ultrastructure Humans Membrane Proteins / genetics, isolation & purification, metabolism* Molecular Sequence Data Plaque, Amyloid / genetics, metabolism* RNA, Messenger / metabolism Rats Sequence Homology, Amino Acid Transcriptional Activation / genetics Up-Regulation / genetics |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; 0/Mib protein, rat; 0/PIEZO1 protein, human; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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