| A novel maturation marker for human Sertoli cells. | |
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MedLine Citation:
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PMID: 2687179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The maturation of Sertoli cells at puberty is critical for the initiation and maintenance of spermatogenesis. Little is known about the factors which control Sertoli cell maturation. We have examined Sertoli cells in testicular specimens from 44 subjects, ranging in age from 6 months to 67 years, for reactivity with a mouse monoclonal antibody (M2A) using the immunoperoxidase reaction. We found positive reactivity with prepubertal but not postpubertal Sertoli cells, suggesting that the antigen defined by M2A was a marker of immature Sertoli cells. This marker may be useful for studying the factors which influence Sertoli cell maturation during development of the testis. |
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Authors:
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R Baumal; D Bailey; A Giwercman; N Skakkebaek; M Stratis; A Marks |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of andrology Volume: 12 ISSN: 0105-6263 ISO Abbreviation: Int. J. Androl. Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1990-01-23 Completed Date: 1990-01-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8000141 Medline TA: Int J Androl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 354-9 Citation Subset: IM |
Affiliation:
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Department of Pathology, Hospital for Sick Children, Toronto, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aging / physiology* Antibodies, Monoclonal / immunology Antigens / analysis Biological Markers / analysis Child Humans Immunoenzyme Techniques Male Middle Aged Sertoli Cells / analysis*, cytology, immunology Testis / cytology*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antigens; 0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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