Document Detail

A novel linkage to generalized vitiligo on 4q13-q21 identified in a genomewide linkage analysis of Chinese families.
MedLine Citation:
PMID:  15809929     Owner:  NLM     Status:  MEDLINE    
Generalized vitiligo is a common, autoimmune, familial-clustering depigmentary disorder of the skin and hair that results from selective destruction of melanocytes. Generalized vitiligo is likely a heterogeneous disease, with five susceptibility loci reported so far--on chromosomes 1p31, 6p21, 7q, 8p, and 17p13--in white populations. To investigate vitiligo susceptibility loci in the Chinese population, we performed a genomewide linkage analysis in 57 multiplex Chinese families, each with at least two affected siblings, and we identified interesting linkage evidence on 1p36, 4q13-q21, 6p21-p22, 6q24-q25, 14q12-q13, and 22q12. Subsequently, to extract more linkage information, we investigated our initial genomewide linkage findings in a follow-up analysis of 49 new families and additional markers. Our initial genomewide linkage analysis and our subsequent follow-up analysis have identified a novel linkage to vitiligo on 4q13-q21, with highly significant linkage evidence (a nonparametic LOD score of 4.62 [P=.000003] and a heterogeneity LOD score of 4.01, under a recessive inheritance model), suggesting that 4q13-q21 likely harbors a major susceptibility locus for vitiligo in the Chinese population. We observed a minimal overlap between the linkage results of our current genomewide analysis in the Chinese population and the results of previous analyses in white populations, and we thus hypothesize that, as a polygenic disorder, vitiligo may be associated with great genetic heterogeneity and a substantial difference in its genetic basis between ethnic populations.
Jian-Jun Chen; Wei Huang; Jin-Ping Gui; Sen Yang; Fu-Sheng Zhou; Quan-Geng Xiong; Hong-Bo Wu; Yong Cui; Min Gao; Wei Li; Jin-Xian Li; Kai-Lin Yan; Wen-Tao Yuan; Shi-Jie Xu; Jian-Jun Liu; Xue-Jun Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-04
Journal Detail:
Title:  American journal of human genetics     Volume:  76     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-06     Completed Date:  2005-07-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1057-65     Citation Subset:  IM    
Institute of Dermatology and Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
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MeSH Terms
China / epidemiology
Chromosomes, Human, Pair 4*
Genetic Heterogeneity
Genetic Markers
Genome, Human*
Linkage (Genetics)*
Lod Score
Models, Genetic
Nuclear Family*
Statistics, Nonparametric
Vitiligo / epidemiology*,  genetics*
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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