Document Detail

The novel ischemia marker 'ischemia-modified albumin' is increased in normal pregnancies.
MedLine Citation:
PMID:  19235558     Owner:  NLM     Status:  MEDLINE    
The aim of this prospective case-control study was to determine the change in serum maternal ischemia-modified albumin (IMA) during normal pregnancies. A total of 117 pregnant (first trimester (n=24), second trimester (n=34), and third trimester (n=35)) and non-pregnant healthy women (n=23) were included. Maternal serum IMA, Malondialdehyde (MDA), and albumin levels were measured. Compared with non-pregnant women, the cross-sectional mean IMA levels in pregnant women were significantly increased, while the mean serum MDA and albumin levels were significantly decreased throughout pregnancy. Furthermore, a significant negative correlation between serum IMA and albumin levels (r=-0.354, p<0.001) was found, and there was a weak positive correlation between serum albumin and MDA levels (r=0.334, p<0.001). Serum IMA, which has recently been developed as a clinical marker of ongoing myocardial ischemia, appears to be elevated in normal pregnancy. This may be due to the physiologic oxidative stress state of pregnancy.
Suleyman Guven; Ahmet Alver; Ahmet Mentese; F Ceylan Ilhan; Mustafa Calapoglu; Mesut A Unsal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  88     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2009  
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  479-82     Citation Subset:  IM    
Department of Obstetric and Gynecology, Karadeniz Technical University, Trabzon, Turkey.
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MeSH Terms
Biological Markers / blood,  metabolism
Case-Control Studies
Cross-Sectional Studies
Gestational Age
Ischemia / blood*
Malondialdehyde / blood
Oxidative Stress
Pregnancy / blood*,  physiology
Prospective Studies
Serum Albumin / analysis*,  biosynthesis*
Reg. No./Substance:
0/Biological Markers; 0/Serum Albumin; 542-78-9/Malondialdehyde

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