Document Detail

A novel hypothesis for the psycho-modulating effects of lithium: the role of essential fatty acids, eicosanoids and sub-cellular second messengers.
MedLine Citation:
PMID:  2190069     Owner:  NLM     Status:  MEDLINE    
Evidence is presented for a novel proposal for the mechanism of action of lithium in manic depressive psychosis. Lithium has well established effects on catecholaminergic--and hormone--stimulated adenyl cyclase activity and on cyclic AMP formation. Although there is conflicting evidence in the literature concerning the effects of the ion on cyclic nucleotide phosphodiesterase, not much is known of the effects of lithium on cyclic GMP. These two second messengers have been proposed to be mutually antagonistic in their actions but that a physiological balance between the two is essential for maintaining homeostasis of the human psyche. An in vivo animal study was undertaken to determine the effects of chronic lithium treatment on the dynamics and kinetics of these two cyclic nucleotides and phosphodiesterase in rat cerebral cortex. From these results, a possible functional coupling mechanism between the two second messenger systems and the effects of lithium are proposed. Lithium by means of its specific site of action, is unique among psychoactive drugs in that it can control both phases of bipolar illness. This point of action is proposed to be the metabolism of free fatty acids where lithium, by altering the availability of precursors for eicosanoid metabolism, is able to modulate both noradrenergic- and cholinergic-dependent pathways. By doing this, the ion is able to reestablish lost control over adrenergic and cholinergic balance critical for thought process and mood stability.
B H Harvey; M E Carstens; J J Taljaard
Related Documents :
108039 - Absence of oroticaciduria in adenosine deaminase deficiency and purine nucleoside phosp...
19140839 - A novel hla-cw*0436 allele identified by haplotype-specific extraction and sequence-bas...
2411399 - Enhancement by uridine of the anabolism of 5-fluorouracil in mouse t-lymphoma (s-49) ce...
9527969 - Glutamine and nucleotide metabolism within enterocytes.
12010479 - Pyrimidine nucleotide and nucleic acid synthesis in embryos and megagametophytes of whi...
6780519 - Induction of bacillus subtilis sporulation by nucleosides: inosine appears to be sporogen.
23961169 - Consequence of the antioxidant activities and tyrosinase inhibitory effects of various ...
287729 - Accidental hydrofluoric acid burns of the hand.
1980429 - Reexamination of dopamine as the prolactin-release inhibiting factor (pif): supplementa...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical hypotheses     Volume:  32     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-07-12     Completed Date:  1990-07-12     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  51-8     Citation Subset:  IM    
Department of Chemical Pathology, University of Stellenbosch, Tygerberg, Republic of South Africa.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Eicosanoids / physiology
Fatty Acids, Essential / physiology
Lithium / pharmacology*
Psychotropic Drugs / pharmacology
Second Messenger Systems / drug effects
Reg. No./Substance:
0/Eicosanoids; 0/Fatty Acids, Essential; 0/Psychotropic Drugs; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Are changes in expression of actin genes involved in estrogen-induced cholestasis?
Next Document:  Are B lymphocytes involved in allograft/tumor rejection and GVH?