Document Detail


A novel human derived cell-penetrating peptide in drug delivery.
MedLine Citation:
PMID:  21080077     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cell-penetrating peptides can carry a variety of biologically active molecules into cells. Here we have identified a novel CPP derived from the C-terminus of human extracellular superoxide dismutase (hC-SOD3) which was shown to be located throughout in the cytoplasm and nucleus by fluorescence microscopy investigation. Furthermore, when apoptin fused to hC-SOD3, it was translocated efficiently into HeLa cells resulting in antitumor activities. This study shows that hC-SOD3 has the potential to penetrate and translocate cargo molecules into cells and has no cytotoxicity at effective concentration.
Authors:
Jian Zhao; Peng Gao; Wei Xiao; Li-Qiang Fan; Fu-Jun Wang; Su-Xia Li; Jian-Wen Liu
Related Documents :
1156937 - Effect of colchicine on the secretion of matrices of dentine and enamel in the rat inci...
19252097 - Negligible contribution of coronary adventitial fibroblasts to neointimal formation fol...
2439607 - Relationship between cell differentiation and binding of fluorescein isothiocyanate (fi...
12579567 - Rgta modulates the healing pattern of a defect in a monolayer of osteoblastic cells by ...
1716177 - Study of the biological effects of theophylline on v79 cells: viability, membrane perme...
17524637 - Enhancement of docetaxel efficacy in head and neck cancer treatment by g0 cell stimulat...
Publication Detail:
Type:  Journal Article     Date:  2010-11-16
Journal Detail:
Title:  Molecular biology reports     Volume:  38     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2649-56     Citation Subset:  IM    
Affiliation:
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Mailbox 365, 130 Meilong Road, Shanghai, 200237, People's Republic of China, zhaojian@ecust.edu.cn.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Variations in bran carotenoid levels within and between rice subgroups.
Next Document:  Characterization of SSU5C promoter of a rbcS gene from duckweed (Lemna gibba).