| A novel histological lesion in glucocorticoid-responsive chronic hepatitis. | |
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MedLine Citation:
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PMID: 9247489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In patients with chronic hepatitis, the diagnosis of autoimmune hepatitis is made on the basis of increased gamma-globulin levels and the presence of circulating autoantibodies. Because these test results are not abnormal universally in patients with autoimmune hepatitis, liver biopsy remains an important part of the evaluation. The classical histological finding in autoimmune hepatitis is lymphocytic infiltration of the portal triads and periportal zone (zone 1) with periportal hepatocyte necrosis. This case report describes 4 patients with glucocorticoid-responsive hepatitis, presumably autoimmune in nature, who had pericentral necrosis (zone 3) with relative sparing of the portal areas in their liver biopsy specimens, a previously undescribed histological finding in autoimmune hepatitis. |
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Authors:
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D S Pratt; K A Fawaz; A Rabson; R Dellelis; M M Kaplan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 113 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-08-26 Completed Date: 1997-08-26 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 664-8 Citation Subset: AIM; IM |
Affiliation:
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Division of Gastroenterology, New England Medical Center, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoantibodies / analysis Autoimmune Diseases / diagnosis, drug therapy*, pathology* Biopsy / methods Female Glucocorticoids / therapeutic use* Hepatitis, Chronic / diagnosis, drug therapy*, pathology* Humans Liver / pathology* Male Middle Aged gamma-Globulins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Glucocorticoids; 0/gamma-Globulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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