| A novel guanine exchange factor increases the competence of early ectoderm to respond to neural induction. | |
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MedLine Citation:
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PMID: 10525189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inductive interactions between different cell layers have an extremely important role in early embryogenesis. One of the most intensively studied and best characterised of these is the induction of neural tissue from ectodermal cells by the dorsal mesoderm. The competence of ectodermal cells to respond to neural induction varies according to dorsal-ventral position; with dorsal ectoderm (much of which forms the neural plate) having a far higher competence. Here we show that overexpression of the nucleotide exchange factor lfc increases ectodermal competence for neural induction as well as the amount of neural tissue in the whole embryo. Lfc is expressed pan ectodermally soon after gastrulation and may respond to an early determinant of dorsal ectoderm. |
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Authors:
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R Morgan; M H Hooiveld; A J Durston |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mechanisms of development Volume: 88 ISSN: 0925-4773 ISO Abbreviation: Mech. Dev. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 2000-08-16 Completed Date: 2000-08-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9101218 Medline TA: Mech Dev Country: IRELAND |
Other Details:
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Languages: eng Pagination: 67-72 Citation Subset: IM |
Affiliation:
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Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, Netherlands. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AF159239 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins / genetics, metabolism Carrier Proteins Cloning, Molecular Diglycerides / metabolism Ectoderm / physiology* Embryo, Nonmammalian Embryonic Induction / genetics Epidermis / embryology, physiology Gene Expression Regulation, Developmental Guanine Nucleotide Exchange Factors / genetics Molecular Sequence Data Nervous System / embryology* Neural Crest / physiology Proteins / genetics, metabolism Proto-Oncogene Proteins / genetics*, metabolism Xenopus / embryology, genetics* Xenopus Proteins |
| Chemical | |
Reg. No./Substance:
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0/Arhgef2 protein, mouse; 0/Bmp4 protein, mouse; 0/Bone Morphogenetic Protein 4; 0/Bone Morphogenetic Proteins; 0/Carrier Proteins; 0/Diglycerides; 0/Guanine Nucleotide Exchange Factors; 0/Proteins; 0/Proto-Oncogene Proteins; 0/Xenopus Proteins; 0/bmp4 protein, Xenopus; 148294-77-3/noggin protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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